PMID: 7541693Apr 1, 1995Paper

Increase by NG-nitro-L-arginine methyl ester (L-NAME) of resistance to venous return in rats

British Journal of Pharmacology
Y X WangC C Pang

Abstract

1. The effects of the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on mean circulatory filling pressure (MCFP), total peripheral resistance (TPR), cardiac output (CO) and resistance to venous return (Rv) were studied in rats. 2. In conscious, unrestrained rats, L-NAME (0.5-16 mg kg-1) dose-dependently increased mean arterial pressure (MAP) but not MCFP, an inverse index of venous compliance, either in the absence or presence of the ganglionic blocker mecamylamine (10 mg kg-1). 3. In pentobarbitone-anaesthetized rats, L-NAME (2, 4, 8 mg kg-1) increased MAP and reduced CO in a dose-related manner but did not change MCFP, TPR (+84, +140 and +192%) as well as Rv (+62, +72, +110%) were dose-dependently increased by L-NAME. 4. Our results show that L-NAME reduces CO by increasing arterial as well as venous resistances. L-NAME does not affect MCFP.

References

Jun 1, 1992·Hypertension·A A PegoraroW H Beierwaltes
Aug 14, 1992·European Journal of Pharmacology·R TabrizchiC C Pang
May 1, 1992·Cardiovascular Research·R Tabrizchi, C C Pang
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M E GoldL J Ignarro
Nov 13, 1990·European Journal of Pharmacology·H M VargasG Chaudhuri
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Oct 27, 1987·European Journal of Pharmacology·R Tabrizchi, C C Pang
Oct 1, 1993·Journal of Cardiovascular Pharmacology·Y X WangC C Pang
Feb 1, 1993·Journal of Applied Physiology·C F Rothe

❮ Previous
Next ❯

Citations

Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
Sep 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Dongzhe SongCatherine C Y Pang
May 30, 1997·European Journal of Pharmacology·B PalaciosC C Pang
May 29, 2002·Archives of Medical Research·Paavo Pokk, Marika Väli
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paavo Pokk, Marika Väli
Apr 28, 2001·Journal of Pharmacological and Toxicological Methods·C C Pang
Mar 1, 2000·British Journal of Pharmacology·S S Ng, C C Pang
Feb 28, 2002·British Journal of Pharmacology·Beatriz PalaciosCatherine C Y Pang
Jan 23, 1999·Journal of Autonomic Pharmacology·J McDaidJ R Docherty
Nov 20, 1998·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C HablyJ Bartha
Mar 27, 2001·The Journal of Surgical Research·J ForsterJ G Wood
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Aly Mohamed AbdelrahmanCatherine Cheuk Ying Pang
Mar 14, 2014·Journal of Cardiovascular Pharmacology·Joanne Y T Leung, Catherine C Y Pang
Dec 18, 2004·Pharmacology·Aly M AbdelrahmanCatherine C Y Pang
Jul 1, 2006·Journal of Cardiovascular Pharmacology·Keshari M ThakaliStephanie W Watts
Feb 24, 2001·Journal of Cardiovascular Pharmacology·R J JohnsonG D Fink
Aug 1, 1997·Journal of Cardiovascular Pharmacology·F Le Marquer-Domagala, M Finet
Dec 23, 2004·Journal of Cardiovascular Pharmacology·Aly Mohamed Abdelrahman, Catherine Cheuk Ying Pang
Jun 25, 1998·The American Journal of Physiology·A A Nekooeian, C C Pang
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaAsunción Morán
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A A Nekooeian, C C Pang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.