PMID: 9175932May 1, 1997Paper

Increase in age at onset of rheumatoid arthritis in Japan over a 30 year period

Annals of the Rheumatic Diseases
T ImanakaS Wakitani

Abstract

To determine changes in demographic variables and severity of rheumatoid arthritis (RA) that may have occurred during the 30 year period from 1960 to 1990 in Japan. Using records of patients diagnosed with RA from two hospitals, demographic and clinical features at initial visit were compared between two groups, one from 1960 to 1965 (group I) and the other from 1985 to 1990 (group II). Mean age at the time of onset of the disease increased significantly from 37.5 years in group I to 46.9 in group II. The peak age at onset of RA shifted from the third to the fifth decade between group I and group II. There was no obvious change in morbidity as determined by seropositivity, rheumatoid nodules, and assessments of hip involvement. The age at onset of RA was delayed during a recent 30 year period in Japan. This increase in age at onset might result from environmental changes that occurred in Japan or may reflect a birth cohort phenomenon. Improvement of severity of disease was not found in this study.

References

Jan 1, 1989·Scandinavian Journal of Rheumatology. Supplement·A J Silman
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Citations

Mar 29, 2002·Arthritis and Rheumatism·Alan J Silman
Dec 29, 2012·Rheumatology International·Ee Tzun KohUNKNOWN TTSH RA Study Group
May 17, 2005·Clinical Rheumatology·R WesthovensH Mielants
Aug 3, 2004·Annals of the Rheumatic Diseases·T Uhlig, T K Kvien
May 27, 1999·Annals of the Rheumatic Diseases·T UshiyamaS Hukuda
May 26, 2004·PharmacoEconomics·Tore K Kvien
Mar 2, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Sachiko OnishiSeiji Minota
Sep 13, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan WangDa-hong Ju
Jun 15, 2011·Best Practice & Research. Clinical Rheumatology·Loreto CarmonaLyn March
Apr 24, 2014·Arthritis & Rheumatology·Jessica WiddifieldClaire Bombardier
May 8, 1998·Seminars in Arthritis and Rheumatism·K AhoT Klaukka
Feb 17, 2017·International Journal of Rheumatic Diseases·Eri KatoShigeto Tohma
Jan 18, 2018·Immunological Investigations·B R SakrZ O Nawito
Feb 13, 2015·The Open Rheumatology Journal·Maria L E AnderssonIngiäld Hafström
Jul 26, 2019·Rinshō shinkeigaku = Clinical neurology·Yuichi KiraSukehisa Nagano
Jan 5, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Tsuyoshi Takeda
Jul 1, 2004·Annals of Medicine·Kimmo Aho, Markku Heliövaara

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