Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis

Arthritis and Rheumatism
David J HunterDavid T Felson

Abstract

Although bone marrow lesions (BMLs) are powerful predictors of joint space loss as visualized on radiographs, the natural history of these lesions, their relationship to cartilage loss, and the association between change in these lesions and cartilage loss are unknown. These questions were tested using longitudinal magnetic resonance imaging (MRI) data in a natural history study of symptomatic knee osteoarthritis (OA). MRI of the knee was performed at baseline, 15 months, and 30 months in 217 patients with primary knee OA (122 men, 95 women; mean +/- SD age 66.4 +/- 9.4 years). To assess mechanical alignment, long-limb films were obtained at 15 months. Subchondral bone marrow abnormalities, graded in the medial and lateral tibiofemoral joints, were defined as poorly marginated areas of increased signal intensity in the marrow on fat-suppressed, T2-weighted images. Cartilage morphologic features in the medial and lateral tibiofemoral joints were scored at all time points using a semiquantitative scale. For each of the medial and lateral compartments, generalized estimating equations were used to evaluate the longitudinal relationship of tibiofemoral BMLs to the tibiofemoral cartilage score, with adjustment for malalignment. Fift...Continue Reading

Associated Clinical Trials

Feb 25, 2009·David Hunter, David Hunter

References

Aug 1, 1992·The British Journal of Radiology·K NakanishiT Kozuka
Jul 11, 1992·The American Journal of Sports Medicine·K P SpeerW E Garrett
Nov 1, 1992·Journal of Computer Assisted Tomography·A NeuholdH Plenk
May 1, 1994·Skeletal Radiology·A G BergmanM A Lones
Jul 1, 1994·Radiology·W R ReinusJ H Ritter
Jun 3, 1998·Current Opinion in Rheumatology·D B Burr
May 27, 1999·Annals of the Rheumatic Diseases·T BoegårdK Jonsson
Nov 24, 1999·Osteoarthritis and Cartilage·D R GaleD Felson
Apr 3, 2001·Annals of Internal Medicine·D T FelsonD R Gale
Jul 13, 2001·JAMA : the Journal of the American Medical Association·L SharmaD D Dunlop
Feb 13, 2002·Arthritis and Rheumatism·Olivier BeufSharmila Majumdar
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Vikas PatelSharmila Majumdar
Sep 11, 2003·Annals of Internal Medicine·David T FelsonDaniel Gale
Feb 20, 2004·Osteoarthritis and Cartilage·C G PeterfyH K Genant

❮ Previous
Next ❯

Citations

Feb 8, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Craig WallerNicholas J London
Nov 28, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y HenrotinC Sanchez
Aug 19, 2011·Skeletal Radiology·Ulrich WeberWalter P Maksymowych
Apr 7, 2010·Rheumatology International·Massoud Daheshia, Jian Q Yao
Oct 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Mitsuaki KubotaKazuo Kaneko
Feb 2, 2013·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Hollis G Potter, Matthew F Koff
Nov 22, 2007·Nature Clinical Practice. Rheumatology·Changhai DingGraeme Jones
Jan 17, 2013·Nature Reviews. Rheumatology·Ali GuermaziDaichi Hayashi
Dec 5, 2008·Age and Ageing·Fraser Birrell, David Felson
Jun 28, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shari Miura LingLuigi Ferrucci
Aug 20, 2010·Rheumatology·Patricia A BerryFlavia M Cicuttini
Sep 1, 2007·Current Opinion in Rheumatology·Felix EcksteinDavid Hunter
Aug 14, 2008·Current Opinion in Rheumatology·Sadaf Ashraf, David Andrew Walsh
Apr 3, 2009·Current Opinion in Rheumatology·David J HunterFelix Eckstein
Oct 20, 2012·Current Opinion in Rheumatology·Changhai DingDavid Hunter
Aug 14, 2010·International Journal of Rheumatic Diseases·Hassan M Bassiouni
Sep 8, 2012·Annals of the Rheumatic Diseases·Frank W RoemerUNKNOWN MOST study investigators
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Yuanyuan WangFlavia M Cicuttini
Aug 4, 2012·Therapeutic Advances in Musculoskeletal Disease·Steven R Goldring
Aug 4, 2012·Therapeutic Advances in Musculoskeletal Disease·Tuhina Neogi
Feb 18, 2012·BMC Musculoskeletal Disorders·Andrew J TeichtahlFlavia M Cicuttini
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.