PMID: 19066081Dec 11, 2008Paper

Increase in brain thrombin activity after experimental intracerebral hemorrhage

Acta Neurochirurgica. Supplement
Ye GongYa Hua

Abstract

Thrombin has been shown to play a major role in brain injury after intracerebral hemorrhage (ICH). In this study, we measured thrombin activity in the perihematomal zone and examined the role of thrombin in ICH-induced brain tissue loss. There were 2 experiments in this study. In the first part, adult male Sprague-Dawley rats received 100 microL of either autologous whole blood or saline. The rats were killed at 1 h or 24 h later for thrombin activity measurement. Thrombin activity was measured using the thrombin-specific chromogenic substrate, S2238. In the second part, rats received a 50-microL intracaudate injection of either thrombin or saline, and the rats were killed at days 1, 3, or 28 for determination of neuronal death and brain tissue loss. We found that brain thrombin activity was elevated in ipsilateral basal ganglia 1 h after ICH. Intracerebral injection of thrombin rather than saline caused significant neuronal death at days 1 and 3, and resulted in significant brain tissue loss at day 28. These results suggest that thrombin inhibition in the acute phase may reduce ICH-induced brain damage.

Citations

Nov 11, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jayalakshmi CaliaperumalFrederick Colbourne
Dec 6, 2014·Frontiers in Cellular Neuroscience·Eva Mracsko, Roland Veltkamp
Dec 8, 2015·Reviews in the Neurosciences·Abubakar Tijjani SalihuJafri Malin Abdullah
Nov 15, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chun-Shu PiaoMark S Wainwright
Dec 17, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Serdar KayaSebahattin Cureoglu
Sep 30, 2020·Translational Stroke Research·Fenghui YeGuohua Xi
Mar 23, 2017·Journal of the Neurological Sciences·Qianwei ChenZhi Chen
Jun 3, 2021·International Journal of Molecular Sciences·Jesse A StokumJ Marc Simard

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