Increase in c-Fos and Arc protein in retrosplenial cortex after memory-improving lateral hypothalamic electrical stimulation treatment

Neurobiology of Learning and Memory
E KádárP Segura-Torres

Abstract

Post-training Intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH), a kind of rewarding deep-brain stimulation, potentiates learning and memory and increases c-Fos protein expression in specific memory-related brain regions. In a previous study, Aldavert-Vera et al. (2013) reported that post-acquisition LH-ICSS improved 48 h retention of a delay two-way active avoidance conditioning (TWAA) and induced c-Fos expression increase in CA3 at 90 min after administration. Nevertheless, this c-Fos induction was only observed after the acquisition session and not after the retention test at 48 h, when the ICSS improving effect was observed on memory. This current study aims to examine the hypothesis that post-training ICSS treatment may stimulate c-Fos expression at the time of the TWAA retention test in retrosplenial cortex (RSC), a hippocampus-related brain region more closely related with long-lasting memory storage. Effects of ICSS on Arc protein, a marker of memory-associated synaptic plasticity, were also measured by immunohistochemistry in granular and agranular RSC. The most innovative results are that the ICSS treatment potentiates the c-Fos induction across TWAA conditions (no conditioning, acquisition and ret...Continue Reading

References

Jan 8, 1992·The Journal of Comparative Neurology·T van Groen, J M Wyss
Jun 24, 2003·The Journal of Comparative Neurology·Thomas Van Groen, J Michael Wyss
Jun 3, 2005·Neuroreport·Eiichi TabuchiHisao Nishijo
Oct 29, 2005·The Journal of Comparative Neurology·Joseph L Price
Aug 1, 2006·Behavioural Brain Research·Nikolai V Lukoyanov, Elena A Lukoyanova
Oct 13, 2007·Neurobiology of Learning and Memory·Teiko MiyashitaJohn F Guzowski
Jun 3, 2008·Behavioral Neuroscience·Christopher S Keene, David J Bucci
Sep 19, 2009·Neurobiology of Learning and Memory·Pilar Segura-TorresIgnacio Morgado-Bernal
Oct 6, 2009·Neuropsychologia·John P Aggleton
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cynthia KatcheJorge H Medina
Jun 22, 2011·Behavioral Neuroscience·Siobhan RobinsonDavid J Bucci
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin A CorcoranJelena Radulovic
Nov 17, 2011·Neuroscience and Biobehavioral Reviews·Christa K McIntyreCedric L Williams
Jan 29, 2013·Hippocampus·Cynthia KatcheJorge H Medina
Jul 9, 2013·Neurobiology of Learning and Memory·Cynthia KatcheJorge H Medina
Mar 8, 2014·Neurobiology of Learning and Memory·Jayme R McReynoldsChrista K McIntyre
Aug 12, 2014·Behavioural Brain Research·Elisabet KádárPilar Segura-Torres
Aug 21, 2014·Frontiers in Human Neuroscience·Adam M P MillerDavid M Smith
Dec 17, 2014·Neuroscience Research·Yoshiko Honda, Norio Ishizuka
May 9, 2015·Frontiers in Behavioral Neuroscience·Alberto J López, Marcelo A Wood
Sep 18, 2015·Neural Plasticity·Travis P Todd, David J Bucci

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Citations

Jul 28, 2016·Behavioural Brain Research·Thomaz Lüscher DiasGrace Schenatto Pereira
Oct 28, 2016·Behavioural Brain Research·Soleil García-BritoPilar Segura-Torres

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