Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination

Proceedings of the National Academy of Sciences of the United States of America
Hawra KarimSeema Tiwari-Woodruff

Abstract

Estrogen receptor β (ERβ) ligands promote remyelination in mouse models of multiple sclerosis. Recent work using experimental autoimmune encephalomyelitis (EAE) has shown that ERβ ligands induce axon remyelination, but impact peripheral inflammation to varying degrees. To identify if ERβ ligands initiate a common immune mechanism in remyelination, central and peripheral immunity and pathology in mice given ERβ ligands at peak EAE were assessed. All ERβ ligands induced differential expression of cytokines and chemokines, but increased levels of CXCL1 in the periphery and in astrocytes. Oligodendrocyte CXCR2 binds CXCL1 and has been implicated in normal myelination. In addition, despite extensive immune cell accumulation in the CNS, all ERβ ligands promoted extensive remyelination in mice at peak EAE. This finding highlights a component of the mechanism by which ERβ ligands mediate remyelination. Hence, interplay between the immune system and central nervous system may be responsible for the remyelinating effects of ERβ ligands. Our findings of potential neuroprotective benefits arising from the presence of CXCL1 could have implications for improved therapies for multiple sclerosis.

References

Nov 22, 2000·Molecular and Cellular Neurosciences·X GaoB Popko
May 18, 2001·Brain Research. Developmental Brain Research·D Nguyen, M Stangel
Jun 5, 2002·Journal of Neuroimmunology·Torben L SørensenFinn Sellebjerg
Sep 27, 2002·Annals of Neurology·Nancy L SicotteRhonda R Voskuhl
Sep 11, 2003·Developmental Neuroscience·R FilipovicN Zecevic
Sep 23, 2003·Endocrinology·Heather A HarrisJames C Keith
Dec 2, 2004·Expert Opinion on Biological Therapy·Ronald B MossDennis J Carlo
Mar 19, 2005·Brain : a Journal of Neurology·Kakuri M OmariCedric S Raine
May 4, 2005·Pharmacology & Therapeutics·Jaime ImitolaSamia J Khoury
Aug 9, 2005·Glia·Kakuri M OmariCedric S Raine
Apr 21, 2006·American Journal of Physiology. Cell Physiology·Seema Tiwari-WoodruffJeff Bronstein
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roumen BalabanovBrian Popko
Jun 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurie Beth J MoralesRhonda R Voskuhl
Jan 2, 2007·Journal of Neuroimmunology·Lisa K Peterson, Robert S Fujinami
Jan 31, 2007·Annals of the New York Academy of Sciences·Halina Offner, Magdalena Polanczyk
Aug 23, 2007·Nature Immunology·Henry F McFarland, Roland Martin
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Seema Tiwari-WoodruffRhonda R Voskuhl
Oct 3, 2007·Glia·Radmila Filipovic, Nada Zecevic
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Dec 20, 2008·The American Journal of Pathology·Kakuri M OmariCedric S Raine
Dec 8, 2009·Medicinal Research Reviews·Filippo MinutoloJohn A Katzenellenbogen
Aug 5, 2010·Clinical and Experimental Immunology·J M FletcherK H G Mills
Sep 23, 2010·Brain : a Journal of Neurology·Daniel K CrawfordSeema K Tiwari-Woodruff
Oct 30, 2010·Brain Pathology·Mario MangiardiSeema K Tiwari-Woodruff
Feb 23, 2011·Journal of Visualized Experiments : JoVE·Paula A Pino, Astrid E Cardona
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Aug 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karine LéluJean-Charles Guéry
Oct 3, 2012·American Journal of Reproductive Immunology : AJRI·Danica K HickeyCharles R Wira
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna J KhalajSeema Kaushalya Tiwari-Woodruff
Nov 19, 2013·Drugs·E Jolanda MünzelAnna Williams
May 9, 2014·American Journal of Reproductive Immunology : AJRI·Severina N Haddad, Charles R Wira
Dec 3, 2014·Proceedings of the National Academy of Sciences of the United States of America·Spencer M MooreSeema Kaushalya Tiwari-Woodruff
Jun 5, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edel HennessyColm Cunningham
Aug 5, 2015·The Journal of Infectious Diseases·Sandra LasarteMiguel Relloso
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria AggelakopoulouVily Panoutsakopoulou

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Citations

Dec 19, 2019·DNA and Cell Biology·Dominic D Skinner, Thomas E Lane
Jul 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Alexandra Pérez-SorianoUNKNOWN Catalan MSA registry (CMSAR)
Oct 22, 2019·Frontiers in Neurology·Lukas D LandeggerKonstantina M Stankovic
Oct 23, 2019·Cells·Alessandro MaglioneMarinella Clerico
Jan 7, 2021·Metabolic Brain Disease·Soudeh Ghafouri-FardMohammad Taheri
Dec 23, 2020·Neurotoxicology·Vanessa NaffaaAnne-Laure Schang
Dec 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Kelly L MonaghanEdwin C K Wan

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Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

ImageJ

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