Increase in cholinergic modulation with pyridostigmine induces anti-inflammatory cell recruitment soon after acute myocardial infarction in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Juraci Aparecida RochaFernanda Consolim-Colombo

Abstract

We tested the hypothesis that an increase in the anti-inflammatory cholinergic pathway, when induced by pyridostigmine (PY), may modulate subtypes of lymphocytes (CD4+, CD8+, FOXP3+) and macrophages (M1/M2) soon after myocardial infarction (MI) in rats. Wistar rats, randomly allocated to receive PY (40 mg·kg(-1)·day(-1)) in drinking water or to stay without treatment, were followed for 4 days and then were subjected to ligation of the left coronary artery. The groups-denominated as the pyridostigmine-treated infarcted (IP) and infarcted control (I) groups-were submitted to euthanasia 3 days after MI; the heart was removed for immunohistochemistry, and the peripheral blood and spleen were collected for flow cytometry analysis. Noninfarcted and untreated rats were used as controls (C Group). Echocardiographic measurements were registered on the second day after MI, and heart rate variability was measured on the third day after MI. The infarcted groups had similar MI areas, degrees of systolic dysfunction, blood pressures, and heart rates. Compared with the I Group, the IP Group showed a significant higher parasympathetic modulation and a lower sympathetic modulation, which were associated with a small, but significant, increase i...Continue Reading

References

Aug 1, 1994·Journal of the Autonomic Nervous System·A AntonicaN Paolocci
Jul 11, 2002·Cell Death and Differentiation·X J ZhangY F Shi
Oct 18, 2003·Journal of the American College of Cardiology·Eldrin F LewisUNKNOWN CARE Study
Jun 24, 2004·Circulation·Antonio AbbateFilippo Crea
Aug 7, 2004·Autonomic Neuroscience : Basic & Clinical·Pedro Paulo da Silva SoaresMaria Claudia Costa Irigoyen
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Machteld M TiemessenLeonie S Taams
Dec 7, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhenping HuKeping Yang
Dec 20, 2007·Critical Care Medicine·Stefan HoferMarkus A Weigand
Jul 16, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nikolaos G Frangogiannis
Jun 6, 2009·Journal of Internal Medicine·M Rosas-Ballina, K J Tracey
Mar 25, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ting-Ting TangXiang Cheng
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tamar Harel-AdarSmadar Cohen
Jun 1, 2011·Journal of Cardiac Failure·Cristiano MostardaMaria Claudia Irigoyen
Sep 17, 2011·Science·Mauricio Rosas-BallinaKevin J Tracey
Dec 23, 2011·Basic Research in Cardiology·Ting-Ting TangXiang Cheng
Jun 26, 2012·Immunological Reviews·Peder S OlofssonKevin J Tracey
Jun 29, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Paula S AzevedoLeonardo A M Zornoff
Dec 26, 2012·Trends in Cardiovascular Medicine·Christoph LeibZiya Kaya
Jan 30, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshihisa Anzai
Apr 18, 2013·EMBO Molecular Medicine·Almudena Ortega-GómezOliver Soehnlein
May 7, 2013·Journal of Molecular and Cellular Cardiology·Xiaoxiang YanMotoaki Sano
May 25, 2013·Clinical and Experimental Pharmacology & Physiology·Raquel N de La FuenteMaria-Cláudia Irigoyen
Aug 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Renata M LataroHelio C Salgado
Aug 24, 2013·Clinical and Experimental Pharmacology & Physiology·Colleen J Thomas
Jul 22, 2014·Mediators of Inflammation·Bruno RodriguesMaria-Cláudia Irigoyen
Sep 25, 2014·Basic Research in Cardiology·Vasundhara KainGanesh V Halade

❮ Previous
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Citations

Sep 21, 2016·Mediators of Inflammation·Hélio José Coelho JuniorBruno Rodrigues
Jun 19, 2017·Respiratory Physiology & Neurobiology·Gabriela de Cássia Sousa AmancioOlivier Cazorla
Feb 28, 2018·Frontiers in Physiology·Daniele J FerianiBruno Rodrigues
Nov 18, 2017·PloS One·Larissa Carbonera CandeoAnna Carolina Ratto Tempestini Horliana
Sep 11, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Aline Sterque VillacortaAntônio Cláudio Lucas da Nóbrega
Jun 5, 2019·JCI Insight·Cibele Rocha-ResendeDouglas L Mann
Jun 11, 2017·Journal of Neuroinflammation·K M DanikowskiB S Prabhakar
Oct 24, 2017·Scientific Reports·Otávio C BezerraFernanda M Consolim-Colombo
Feb 15, 2019·Frontiers in Immunology·Jun-Yan XuYue-Jin Yang
Apr 2, 2020·Bioelectronic Medicine·Emma B BrandtAhmed I Mahmoud
Dec 3, 2020·American Journal of Physiology. Cell Physiology·Cibele Rocha-ResendeSilvia Guatimosim
Apr 2, 2021·Frontiers in Cardiovascular Medicine·Haihua QiuYuan Guo
May 4, 2021·Frontiers in Immunology·Namrita Halder, Girdhari Lal
Apr 23, 2021·Acta Physiologica·Gisele L CavalcanteJoão Paulo J Sabino
Jun 27, 2021·International Immunology·Katsuhito Fujiu, Ichiro Manabe
Jul 22, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Wei-Lun LiuHeng-Liang Lin

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