Increase in dicentric chromosome formation after a single CT scan in adults

Scientific Reports
Yu AbeAkira Sakai

Abstract

Excess risk of leukemia and brain tumors after CT scans in children has been reported. We performed dicentric chromosome assay (DCAs) before and after CT scan to assess effects of low-dose ionizing radiation on chromosomes. Peripheral blood (PB) lymphocytes were collected from 10 patients before and after a CT scan. DCA was performed by analyzing either 1,000 or 2,000 metaphases using both Giemsa staining and centromere-fluorescence in situ hybridization (Centromere-FISH). The increment of DIC formation was compared with effective radiation dose calculated using the computational dosimetry system, WAZA-ARI and dose length product (DLP) in a CT scan. Dicentric chromosome (DIC) formation increased significantly after a single CT scan, and increased DIC formation was found in all patients. A good correlation between the increment of DIC formation determined by analysis of 2,000 metaphases using Giemsa staining and those by 2,000 metaphases using Centromere-FISH was observed. However, no correlation was observed between the increment of DIC formation and the effective radiation dose. Therefore, these results suggest that chromosome cleavage may be induced by one CT scan, and we recommend 2,000 or more metaphases be analyzed in Giem...Continue Reading

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Citations

Feb 14, 2016·Journal of Radiation Research·Yu AbeAkira Sakai
Mar 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vitali MoiseenkoDavid C Lloyd
Mar 25, 2016·Molecular Cytogenetics·Thian T BehPaul Kalitsis
Mar 9, 2018·Journal of Radiation Research·Lin Shi, Satoshi Tashiro
Jun 9, 2018·International Journal of Radiation Biology·Al Maqsudur RashidHanna Moussa
Sep 21, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Younghyun LeeSeongjae Jang
Mar 11, 2020·Radiology·Hiroaki SakaneSatoshi Tashiro
Mar 14, 2020·Health Physics·Hanns Leonhard KaatschBenjamin Valentin Becker
May 21, 2017·Radiation and Environmental Biophysics·Igor K KhvostunovShunichi Yamashita
Oct 21, 2020·International Journal of Surgery Case Reports·Katsuyuki IwatsukiHitoshi Hirata
May 15, 2021·Dento Maxillo Facial Radiology·Niels BelmansSarah Baatout
Jul 25, 2021·International Journal of Molecular Sciences·Clémence BaudinMaria Grazia Andreassi

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Methods Mentioned

BETA
chromosomal aberrations
X-ray

Software Mentioned

Metafer
WAZA
STATA
ARI

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