Increase in dopamine turnover and tyrosine hydroxylase enzyme in hippocampus of rats fed on low selenium diet

Journal of Neuroscience Research
A CastañoA Machado

Abstract

We have studied the turnover of dopamine, noradrenaline, and serotonin and their metabolites in hippocampus of adult female rats that were fed control or selenium-deficient diets during 15 days. Under these circumstances, there was an increase of dopamine turnover (4-fold) in rats fed with selenium-deficient diet with respect to controls and also an increase in the tyrosine hydroxylase activity (75.8%), which was the result of the increase of the amount of the enzyme (2-fold), without significant change in the phosphorylation of the tyrosine hydroxylase. In addition the glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase activities have been studied. After selenium-deficient diet, the enzymatic activities of superoxide dismutase and catalase did not show change with respect to the controls; however glutathione reductase and glutathione peroxidase significantly decreased 15% and 29%, respectively. It is concluded that the increase in dopamine turnover seems to be associated with the induction of tyrosine hydroxylase enzyme. In these conditions the decrease in antioxidant capacity may produce a cascade of events, which accelerates the degenerative process, since the increase in dopamine turnover prod...Continue Reading

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Citations

Jun 27, 1997·International Journal of Cardiology·S S Kothari
Dec 13, 2000·Brain Research. Molecular Brain Research·M Romero-RamosA Machado
Jun 1, 1997·Brain Research. Molecular Brain Research·J A Rodríguez-GómezA Machado
Jun 1, 1997·Neurochemistry International·A CastañoA Machado
Jan 12, 2010·Molecular Genetics and Metabolism·Kevin A StraussD Holmes Morton
Sep 15, 2015·Pharmacology, Biochemistry, and Behavior·Roberto Laureano-MeloWellington da Silva Côrtes
Jan 2, 2003·Nutritional Neuroscience·David Benton
Feb 15, 2002·Nutritional Neuroscience·P D Whanger
Mar 26, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dusan Backović
Apr 30, 2021·Heliyon·Priyanka D PinkyMuralikrishnan Dhanasekaran

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