PMID: 9426702Jan 14, 1998Paper

Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester

International Journal of Cancer. Journal International Du Cancer
T YamamotoH Kosaka

Abstract

As we have previously reported, intraperitoneal injections of NG-nitro-L-arginine methyl ester [L-NAME; a competitive inhibitor of nitric oxide (NO) synthase] before and after the injection of B16 melanoma cells through a tail vein increased experimental pulmonary metastasis, while simultaneous injections of L-arginine (a substrate of NO synthase) at a 20-fold higher dose synergistically increased pulmonary metastasis. Our present study was intended to elucidate the mechanisms by which L-NAME alone or together with L-arginine increases metastasis. Injections of L-NAME decreased the serum concentration of nitrite plus nitrate (metabolites of NO) by about 50%, which was not reversed by simultaneous injections of L-arginine. Injections of L-NAME also decreased the diameter of arterioles and venules by 20-30%, while simultaneous injections of L-arginine did not show any significant effect. When collagen- or ADP-induced platelet aggregation was examined using platelet-rich plasma, injections of L-NAME showed little effects on platelet aggregation, while simultaneous injections of L-arginine rather suppressed platelet aggregation. B16 melanoma cells produced NO in culture, and L-NAME (0.2 mM) decreased NO production without effects o...Continue Reading

References

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Citations

Oct 14, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vanessa BattistiVera M Morsch
Apr 30, 2009·The International Journal of Biochemistry & Cell Biology·Martin Mendoza, Chand Khanna
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Lynne-Marie PostovitCharles H Graham
Sep 23, 2006·Medicinal Research Reviews·Simone MocellinDonato Nitti
Jan 28, 2010·International Journal of Cancer. Journal International Du Cancer·Barbara DelagePeter W Szlosarek
Feb 24, 2006·Journal of Cardiovascular Pharmacology·Adam J ChiccoReid Hayward

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