Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
H DubocJ M Sabaté

Abstract

Irritable bowel syndrome (IBS) is a multifactorial disease for which a dysbiosis of the gut microbiota has been described. Bile acids (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in healthy subjects (HS) and patients with diarrhea-predominant IBS (IBS-D), and we searched for an association with symptoms. Clinical features and stool samples were collected in IBS-D patients and HS. Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q-PCR targeting dominant bacterial groups and species implicated in BA transformation. Fourteen IBS-D patients and 18 HS were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in IBS-D patients than in HS, and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of Escherichia coli and a significant decrease of leptum and bifidobacterium in IBS-D patients. We report an increase of primary BA in the f...Continue Reading

References

Nov 1, 1975·Gut·W O KirwanM A Eastwood
Mar 1, 1989·Gut·C A EdwardsN W Read
Aug 1, 1971·The Journal of Clinical Investigation·H S MekjianA F Hofmann
Jan 1, 1982·Digestion·J F Fielding
Apr 1, 1980·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J D FalconerM A Eastwood
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·P A BamptonI J Cook
Aug 28, 2003·Scandinavian Journal of Gastroenterology·S WildtJ J Rumessen
Jan 1, 1964·The British Journal of Nutrition·A NORMAN
Jan 26, 2005·The American Journal of Gastroenterology·Erja MalinenAiri Palva
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J KeelyAlan F Hofmann
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Andreas MünchJohan D Söderholm
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Francesco RaimondiRoberto Paludetto
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Alan F HofmannDale A Chatfield
Nov 13, 2008·Gastroenterology·Richard J TraubYing Sun
Nov 26, 2008·Gastroenterology·Andrew S Neish
Feb 25, 2009·Inflammatory Bowel Diseases·H SokolJ Doré
Mar 24, 2009·FEMS Microbiology Ecology·Jean-Pierre FuretGérard Corthier
Jul 9, 2009·Journal of Cellular and Molecular Medicine·Niamh KeatingStephen J Keely
Sep 11, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S M CollinsP Bercik
Oct 13, 2009·Expert Review of Gastroenterology & Hepatology·Alan F Hofmann
Nov 3, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suwebatu T Odunsi-ShiyanbadeAlan R Zinsmeister
Dec 17, 2009·World Journal of Gastroenterology : WJG·Anna LyraAiri Palva
Mar 26, 2010·Scandinavian Journal of Gastroenterology·Antal BajorHasse Abrahamsson
Feb 22, 2011·Gastroenterology Clinics of North America·Rok Seon Choung, G Richard Locke
Apr 2, 2011·Journal of Gastroenterology and Hepatology·Jinsong Liu, Xiaohua Hou

❮ Previous
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Citations

Oct 26, 2012·The New England Journal of Medicine·Michael Camilleri
Dec 4, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Giles Major, Robin Spiller
Oct 3, 2013·The Journal of Clinical Investigation·Michael Camilleri
Jun 4, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Julius GoeppDarryl Landis
Feb 13, 2013·The British Journal of Nutrition·Virginia Robles Alonso, Francisco Guarner
Jan 15, 2014·Expert Review of Gastroenterology & Hepatology·Michael Camilleri
Feb 1, 2014·Expert Opinion on Biological Therapy·Mitchell L JonesSatya Prakash
Feb 4, 2014·Gastroenterology·Fergus Shanahan, Eamonn M M Quigley
May 4, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrea ShinAlan R Zinsmeister
Dec 27, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Siobhain M O' MahonyJohn F Cryan
Dec 15, 2015·CNS Neuroscience & Therapeutics·Rachel D MoloneyJohn F Cryan
Jan 17, 2016·Annual Review of Food Science and Technology·Susan A Joyce, Cormac G M Gahan
Jun 6, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Richard N Appleby, Julian R F Walters
Feb 26, 2016·Alimentary Pharmacology & Therapeutics·N MottackiA Bajor
Apr 10, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M DiorJ-M Sabate
Feb 24, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A P S HunginN J De Wit
Mar 15, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Imran AzizAlexander C Ford
Jul 9, 2013·Current Opinion in Microbiology·S MiquelP Langella
Jan 22, 2013·Journal of Hepatology·Genta KakiyamaJasmohan S Bajaj
Apr 29, 2015·Gut and Liver·Sean M P BennetMagnus Simren
Apr 29, 2015·Gut and Liver·Michael Camilleri
Jul 12, 2014·Gut Microbes·Mitchell L JonesSatya Prakash
Dec 4, 2012·Gut Microbes·Delphine M SaulnierFrancisco Guarner
Mar 31, 2015·Gastroenterology Research and Practice·Nidhi M SagarRamesh P Arasaradnam
Jul 31, 2013·FEMS Microbiology Ecology·Ana DurbánAndrés Moya
Jul 30, 2016·Gut Microbes·Hans RaskovJacob Rosenberg
Sep 15, 2016·Gut Pathogens·AbdelRahman Mahmoud AlyRamy K Aziz
Dec 3, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H EutamèneE Mas
Nov 20, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cédric PelemanAlan R Zinsmeister
Jan 4, 2017·The ISME Journal·Mireia Lopez-SilesMargarita Martinez-Medina
Jan 5, 2017·Journal of Neurogastroenterology and Motility·Hyo Jeong LeeKyoung Sup Hong
Jan 22, 2014·Nature Reviews. Gastroenterology & Hepatology·Heidi M StaudacherKevin Whelan
Mar 26, 2014·Nature Reviews. Gastroenterology & Hepatology·Julian R F Walters
Jun 13, 2017·Molecular Aspects of Medicine·Sarah L LongSusan A Joyce

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