Increase in gap junction conductance by an antiarrhythmic peptide

European Journal of Pharmacology
A MüllerStefan Dhein

Abstract

Impaired cellular coupling is thought to be a very important factor for the genesis of cardiac arrhythmia. Cellular coupling is mediated by gap junctions. However, there are no therapeutic agents or experimental substances yet that increase cellular coupling. In addition, it has been shown that most antiarrhythmic drugs available now possess serious adverse effects. Thus, there is an urgent need for new antiarrhythmic agents. Previous studies using epicardial mapping in isolated rabbit hearts provided indirect evidence supporting the hypothesis that a newly synthesised antiarrhythmic peptide (Gly-Ala-Gly-4Hyp-Pro-Tyr-CONH2 = AAP10) might act via an increase in cellular, i.e., gap junctional coupling. The aim of the present study was to test this hypothesis. Measurement of the stimulus-response interval in papillary muscle showed a decrease of about 10% after application of 1 microM AAP10. These results are compatible with the hypothesis of AAP10 acting on gap junctions. In order to prove this hypothesis, gap junction conductance was measured directly by performing double-cell voltage-clamp experiments in isolated pairs of guinea-pig myocytes. During a 10 min control period gap junction conductance slowly decreased with a rate o...Continue Reading

References

Jul 1, 1992·Biophysical Journal·H Z WangR D Veenstra
Sep 1, 1985·The Journal of Physiology·P Metzger, R Weingart
Jan 1, 1981·The Journal of General Physiology·D C SprayM V Bennett
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
May 1, 1994·Journal of Cardiovascular Electrophysiology·N J Severs
Dec 1, 1993·Pflügers Archiv : European journal of physiology·W Jarolimek, U Misgeld

❮ Previous
Next ❯

Citations

Mar 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Jennifer A EastonPatricia E M Martin
Nov 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Feb 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Aida Salameh, Stefan Dhein
Jun 15, 2007·The Journal of Membrane Biology·Lene Nygaard AxelsenMorten Schak Nielsen
Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yan LiuLiang Liu
Sep 10, 2002·Peptides·Stefan Dhein
Jan 30, 2009·Cardiovascular Research·Anja HagenStefan Dhein
Jun 19, 2009·Cardiovascular Research·Sevasti-Maria ChaldoupiHarold V M van Rijen
Nov 11, 2005·APMIS. Supplementum·Niklas Rye Jørgensen
Apr 6, 2006·Clinical Medicine & Research·Jifen LiGlenn L Radice
May 1, 2009·Seminars in Immunopathology·Sandrine MorelBrenda R Kwak
May 10, 2005·Journal of Cardiovascular Electrophysiology·Ketil HauganMorten Schak Nielsen
Sep 12, 2007·Basic & Clinical Pharmacology & Toxicology·Anne Louise KjølbyeJørgen S Petersen
Nov 22, 2007·Journal of Internal Medicine·Y Blaauw, H J G M Crijns
Apr 1, 2008·Journal of Cardiovascular Electrophysiology·Marc Cohen, Gerald V Naccarelli
Sep 12, 2007·Expert Opinion on Therapeutic Targets·Deepak Bhakta, John M Miller
Nov 19, 2014·Frontiers in Physiology·Stefan DheinFriedrich-Wilhelm Mohr
Mar 15, 2006·Cell Communication & Adhesion·Ketil HauganJørgen Søberg Petersen
Jun 18, 2002·Cell Communication & Adhesion·S DheinL Polontchouk
May 23, 1998·Circulation Research·G CaleroM Delmar
Sep 22, 2017·Pharmacological Reviews·Luc LeybaertRainer Schulz
Jun 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Anne Louise KjølbyeJorgen Søberg Petersen
Jan 27, 2011·British Journal of Pharmacology·Elke De VuystLuc Leybaert
Jun 19, 2014·Experimental and Therapeutic Medicine·Lei RuanCuntai Zhang
Jan 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dezhi XingJames B Martins
Jun 3, 2021·Journal of Cardiovascular Development and Disease·Spencer R MarshRobert G Gourdie
Mar 23, 2011·Pharmacology & Therapeutics·Jérôme ThireauSylvain Richard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.