Abstract
Due to the increasing numbers of migrants and asylum seekers, hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency are no longer rare diseases in Germany. As a result of the current migration movements these genetically determined diseases will gain in importance. Following a literature search the prevalence of the original endemic regions was compiled and compared to the population composition based on statistical data on migrants, foreign residents and asylum seekers in Germany. In the endemic regions a prevalence of 40 % and sometimes higher have been found for glucose-6-phosphate dehydrogenase deficiency and hemoglobinopathies. The number of people arriving in Germany from these endemic regions is rapidly increasing. Due to the high number of asylum seekers arriving from Asian and African regions, genetic erythrocyte defects will gain importance in the differential diagnosis of anemia; therefore, medical education and training must incorporate heightened awareness of risks, diagnostics and therapy of these disease patterns.
References
May 10, 1991·Science·A H BittlesN A Rao
Nov 1, 1993·American Journal of Hematology·D P SewardT R Kinney
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Dec 13, 2005·Annals of the New York Academy of Sciences·Elliott P Vichinsky
Nov 21, 2007·Hematology·Elliott Vichinsky
Jan 8, 2008·Lancet·M D Cappellini, G Fiorelli
Jun 24, 2008·Bulletin of the World Health Organization·Bernadette Modell, Matthew Darlison
Nov 8, 2008·Blood·Alan N Schechter
Feb 24, 2009·Blood Cells, Molecules & Diseases·Ella T NkhomaErnest Beutler
Aug 13, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ilan YoungsterMatitiahu Berkovitch
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Dec 3, 2011·Evolution; International Journal of Organic Evolution·Bridget S PenmanSunetra Gupta
Aug 22, 2012·BMC Pediatrics·Bushra MoizMaqbool Qadir
Nov 16, 2012·PLoS Medicine·Rosalind E HowesSimon I Hay
Apr 18, 2013·Scientific Reports·Frédéric B PielSimon I Hay
Nov 29, 2013·Archives of Pathology & Laboratory Medicine·Jeanne M RheaRoss J Molinaro
Jul 2, 2014·Orphanet Journal of Rare Diseases·Patricia Aguilar MartinezJoan-Lluis Vives Corrons
Nov 13, 2014·The New England Journal of Medicine·Frédéric B Piel, David J Weatherall
Mar 31, 2015·Revista brasileira de hematologia e hemoterapia·Lidiane de Souza TorresClaudia Regina Bonini-Domingos
May 6, 2015·Tropical Medicine & International Health : TM & IH·Sophie A MüllerFrank P Mockenhaupt
Citations
Sep 17, 2016·Omics : a Journal of Integrative Biology·Khuthala MnikaAmbroise Wonkam
Mar 1, 2017·Pharmacogenomics·Ambroise Wonkam
May 6, 2019·Children·Nina K Friedl, Oliver J Muensterer
Sep 1, 2018·Der Urologe. Ausg. A·A Hofmann, W H Rösch
Feb 6, 2020·Der Nervenarzt·Erich Schmutzhard, Bettina Pfausler
Oct 18, 2020·Orphanet Journal of Rare Diseases·Ana Requena-MéndezAntoni Plasència