Increase in haemoglobin concentrations in growth hormone deficient adults during human recombinant growth hormone replacement therapy

Clinical Endocrinology
S M Ten HaveS W Lamberts

Abstract

Recombinant human growth hormone is being used increasingly in the treatment of GH deficiency in adults. In addition to erythropoietin, insulin-like growth factor-I (IGF-I) has been demonstrated to stimulate hematopoiesis in animals, especially rodents. We have determined the effect of growth hormone (GH) administration on haematopoiesis. Seventeen patients (10 males and 7 females; mean age 47 +/- 2 years; range 30-59) with biochemically proven adult-onset GH deficiency (GHD) were treated with human recombinant growth hormone (rhGH) as replacement therapy for more than 96 weeks in a dosage of 12.5 micrograms/kg/day (initial dosage during the first 4 weeks 6.25 micrograms/kg/day). The diagnosis of GHD had been confirmed using a standard arginine-infusion test (0.5 g/kg body weight). Blood samples were collected for safety and efficacy parameters before and during the GH treatment period. Routine methods were used for the haematological and biochemical measurements. IGF-I concentrations were measured, using a commercial RIA kit. From week 36 and onwards, we observed a significant increase in individual haemoglobin (Hb) concentrations, especially in the male patients. Mean Hb in the male patients before treatment amounted to 9.1 +...Continue Reading

Citations

Jan 23, 1999·Burns : Journal of the International Society for Burn Injuries·K P SinghR J Dash
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S Chappel
May 8, 2007·International Journal of Hematology·Francesco LandiGraziano Onder
Feb 18, 2004·Sports Medicine·Matthias Hütler, Ralph Beneke
Dec 24, 2013·European Journal of Endocrinology·Alberto Giacinto AmbrogioFrancesca Pecori Giraldi
Jun 24, 2006·Journal of Endocrinological Investigation·S BergamaschiP Beck-Peccoz
Aug 25, 2005·Journal of Endocrinological Investigation·H Nishioka, J Haraoka
May 11, 2002·Leukemia & Lymphoma·Walter Zumkeller
Aug 29, 2007·Pediatric Clinics of North America·Sergio R R Buzzini
Aug 31, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P J Jenkins
Sep 1, 1999·Clinical Endocrinology·P J Jenkins
Feb 13, 2016·PloS One·Mikael LehtihetBo Angelin
Apr 10, 2004·Cancer Gene Therapy·Catherine M ToneRuxandra Draghia-Akli
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esmond J Sanders, Steve Harvey
Jun 22, 1999·Journal of the American College of Nutrition·S NishiyamaT Hasuda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.