PMID: 8937878Jan 1, 1996Paper

Increase in heart glutathione redox ratio and total antioxidant capacity and decrease in lipid peroxidation after vitamin E dietary supplementation in guinea pigs

Free Radical Biology & Medicine
C RojasG Barja

Abstract

Dietary treatment with three diets differing in vitamin E, Low E (15 mg of vitamin E/kg diet), Medium E (150 mg/kg), or High E (1,500 mg/kg), resulted in guinea pigs with low (but nondeficient), intermediate, or high heart alpha-tocopherol concentration. Neither the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and reductase, nor the nonenzymatic antioxidants, GSH, ascorbate, and uric acid were homeostatically depressed by increases in heart alpha-tocopherol. Protection from both enzymatic (NADPH dependent) and nonenzymatic (ascorbate-Fe2+) lipid peroxidation was strongly increased by vitamin E supplementation from Low to Medium E whereas no additional gain was obtained from the Medium E to the High E group. The GSH/GSSG and GSH/total glutathione ratios increased as a function of the vitamin E dietary concentration closely resembling the shape of the dependence of heart alpha-tocopherol on dietary vitamin E. The results show the capacity of dietary vitamin E to increase the global antioxidant capacity of the heart and to improve the heart redox status in both the lipid and water-soluble compartments. This capacity occurred at levels six times higher than the minimum daily requirement of vitamin E, ...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Aug 23, 1976·Biochemical and Biophysical Research Communications·R A Lawrence, R F Burk
Sep 30, 1992·Annals of the New York Academy of Sciences·J M GazianoC H Hennekens
Nov 1, 1992·Biological Chemistry Hoppe-Seyler·V D Antonenkov, H Sies
Jan 1, 1991·World Review of Nutrition and Dietetics·E Niki
Jan 1, 1985·Annual Review of Nutrition·P B McCay
Aug 15, 1985·Analytical Biochemistry·A W Bull, L J Marnett
Jul 6, 1984·Biochimica Et Biophysica Acta·T SugaS Horie
May 1, 1995·Journal of Molecular and Cellular Cardiology·P S HaddockD J Hearse
Nov 1, 1995·The International Journal of Biochemistry & Cell Biology·S CadenasG Barja
Aug 1, 1994·Journal of Bioenergetics and Biomembranes·W W Wells, D P Xu
Oct 1, 1994·Journal of Nutritional Science and Vitaminology·C RojasG Barja
Jun 15, 1994·American Journal of Epidemiology·P KnektA Aromaa
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
Jan 1, 1955·Methods of Biochemical Analysis·L SMITH
Jan 1, 1984·Annual Review of Psychology·F W Young

❮ Previous
Next ❯

Citations

Jan 7, 2004·Analytical Biochemistry·Giuseppe LazzarinoBarbara Tavazzi
Jun 25, 2002·Molecular Aspects of Medicine·Helen R GriffithsSiân B Astley
Jan 8, 1999·Neurobiology of Aging·E O'Donnell, M A Lynch
Jun 26, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J L AvanzoM de Cerqueira Cesar
Mar 7, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Tania Y ChristovaMilka S Setchenska
Aug 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K F ShireenA T Khan
Dec 25, 2002·The Tohoku Journal of Experimental Medicine·Gökhan MetinAbidin Kayserilioglu
Mar 7, 2014·Molecular and Cellular Biochemistry·Kailash PrasadA Mabood Qureshi
Sep 16, 2020·Journal of Autism and Developmental Disorders·Shanna L BurkeMarcus S Cooke
Nov 9, 2000·Biochimica Et Biophysica Acta·G E GibsonL C Park
Mar 5, 2003·Biochemical and Biophysical Research Communications·Shweta SoodN P Kurade
Oct 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M G AbubakarGordon A A Ferns
Nov 24, 1999·Journal of Agricultural and Food Chemistry·M RenerreB Métro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.