Increase In Il-31 Serum Levels Is Associated With Reduced Structural Damage In Early Axial Spondyloarthritis

Scientific Reports
Nicolas RosineCorinne Miceli-Richard

Abstract

In spondyloarthritis, little is known about the relation between circulating cytokines and patient phenotype. We have quantified serum levels of T helper type 1 cell (Th1), Th2 and Th17 cytokines in patients with recent-onset axial spondyloarthritis (AxSpA) from the DESIR cohort, a prospective, multicenter French cohort consisting of 708 patients with recent-onset inflammatory back pain (duration >3 months but <3 years) suggestive of AxSpA. Serum levels of Th1, Th2, and Th17 cytokines were assessed at baseline in patients from the DESIR cohort fulfilling the ASAS criteria (ASAS+) and were compared with age- and sex-matched healthy controls. At baseline, ASAS+ patients (n = 443) and healthy controls (n = 79) did not differ in levels of most of the Th1, Th2 and Th17 cytokines except for IL-31, and sCD40L, which were significantly higher for ASAS+ patients than controls (p < 0.001 and p = 0.012, respectively). On multivariable analysis of ASAS+ patients, IL-31 level was associated with sCD40L level (p < 0.0001), modified Stoke AS Spine Score (mSASSS) < 1 (p = 0.035). The multivariable analyses showed that IL-31 was an independent factor associated with mSASSS < 1 (p = 0.001) and low bone mineral density (p = 0.01). Increased level...Continue Reading

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Citations

Mar 7, 2020·International Journal of Immunopathology and Pharmacology·L A Bautista-HerreraJ F Muñoz-Valle
Jul 3, 2020·Immunological Investigations·Ning MuZaixing Yang
Jul 9, 2020·Therapeutic Advances in Musculoskeletal Disease·Mariagrazia LorenzinRoberta Ramonda
Feb 20, 2020·International Journal of Molecular Sciences·Massimo De MartinisLia Ginaldi

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Methods Mentioned

BETA
ELISA
X-ray
bronchoalveolar lavage

Clinical Trials Mentioned

NCT01648907
NCT01831648

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