PMID: 2482377Apr 1, 1989Paper

[Increase in Leu7- Leu11+ cells in the peripheral blood lymphocytes of patients with alopecia areata].

Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology
R ImaiK Takamori

Abstract

Natural killer (NK) cell subsets in the peripheral blood lymphocytes of patients with alopecia areata (AA) were investigated by FACStar-I using NK cell specific monoclonal antibodies. The patients were classified into one of 2 types (Type A: single AA in regrowth phase; Type B: multiple AA, alopecia totalis and alopecia universalis in non-regrowth phase). The percentages of Leu7- Leu11+ cells in Type B were significantly higher than those of the normal control. The increase in Leu7- Leu11+ cells in Type B suggests that NK cells may play an important role in the pathogenesis of AA in the non-regrowth phase.

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