Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats

Acta Neurologica Scandinavica
A B MarcussenU Englund

Abstract

Disturbances in hippocampal neurogenesis may be involved in the pathophysiology of depression and it has been argued that an increase in the generation of new nerve cells in the hippocampus is involved in the mechanism of action of antidepressants. Adult Wistar rats were treated with fluoxetine (10 mg/kg) 1 h, daily for 5 (subchronic) or 28 days (chronic) before the Novelty Suppressed Feeding test was performed. Cell proliferation and neurogenesis were analysed using the markers 5-bromo-deoxy-2'-uridine, Ki-67, and doublecortin. A significant behavioural effect was found after 28 days of fluoxetine administration. However, no behavioural improvement was demonstrated after acute and subchronic treatment with fluoxetine. We further demonstrate that chronic antidepressant treatment increases cell proliferation as well as neurogenesis in the dentate gyrus, here using Wistar rats. In further development of antidepressants, neurogenesis may serve as an important parameter to examine the efficacy and mechanism of action of novel drugs.

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Citations

Sep 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicola D HansonCharles B Nemeroff
Jul 22, 2015·Neuroscience Letters·Xiaoyu SunChuansheng Zhao
Dec 30, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fenghua ChenGregers Wegener
Aug 13, 2020·Biomolecules·Claudia Jorgensen, Zuoxin Wang
Mar 7, 2020·International Journal of Molecular Sciences·Gerardo Bernabé Ramírez-RodríguezNelly Maritza Vega-Rivera

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