Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice.

British Journal of Pharmacology
Daiki UedaHiroko Ikeda

Abstract

Patients with diabetes mellitus are reported to show a raised prevalence of mental disorders, which may be reflected in impaired social interaction. However, the mechanisms underlying such impairment in diabetes are unknown. The present study investigated whether social interaction is impaired in diabetic mice and whether central neuropeptide Y (NPY) and glutamatergic function are involved in such impairment. In the three-chamber test, social novelty preference, but not sociability, was impaired in streptozotocin (STZ)-induced diabetic mice. The mRNA level of NPY in the hypothalamus was increased in STZ-induced diabetic mice. Injection of the NPY Y2 receptor agonist NPY 13-36 into naïve mice impaired social novelty preference, but not sociability, and this effect was inhibited by the Y2 receptor antagonist BIIE 0246. BIIE 0246 also reversed the impairment of social novelty preference in STZ-induced diabetic mice. Similarly, injection of the AMPA receptor agonist AMPA into naïve mice impaired social novelty preference, but not sociability, and this effect was inhibited by the AMPA receptor antagonist NBQX. Impairment of social novelty preference induced by NPY 13-36 was inhibited by NBQX, whereas impairment of social novelty pre...Continue Reading

References

Jun 1, 1997·Brain Research. Molecular Brain Research·E L GustafsonT A Branchek
Mar 11, 1998·Peptides·M NakajimaM Kasuga
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BrobergerT Hökfelt
May 26, 2001·Diabetes Care·R J AndersonP J Lustman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 20, 2002·International Journal of Psychiatry in Medicine·Ryan J AndersonPatrick J Lustman
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shigeo MiyataJunzo Kamei
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Sep 8, 2004·Journal of Neuroscience Research·Gunnar SørensenDavid P D Woldbye
Feb 4, 2005·The Journal of Comparative Neurology·Toshiro KishiJoel K Elmquist
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ikuko SatoYutaka Oiso
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Koji HayashiMikio Ito
Dec 23, 2006·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Vicki S HelgesonDorothy Becker
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuichi AbeHiroyuki Nawa
Apr 19, 2011·Behavioural Brain Research·Xiaojun XiangTherese A Kosten
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ada C Felix-Ortiz, Kay M Tye
Feb 23, 2017·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ramin FarajpourAlireza Majdi
Apr 26, 2017·Behavioural Brain Research·Takuma MiharaSteven J Siegel
Sep 11, 2017·Social Psychiatry and Psychiatric Epidemiology·Aliza Werner-SeidlerTim Slade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.