Increase in nitric oxide formation after chronic voluntary exercise in spontaneously hypertensive rats

Acta Physiologica Scandinavica
I H JonsdottirP Hoffmann

Abstract

The effect of chronic voluntary exercise on the plasma level of nitrate, a major stable metabolite of nitric oxide (NO) was studied in spontaneously hypertensive rats (SHR). Exercise consisted of spontaneous running in wheels for 3-35 days. Blood samples were collected after 3, 7, 14, 21 and 35 days of exercise and all samples were drawn after the running wheel had been locked during the preceding 12 h. The plasma nitrate level was significantly (P < 0.05) elevated in SHR after 35 days of exercise. Surprisingly after 7 days of exercise a significant (P < 0.001) decrease in the nitrate level in plasma was noted. Further research is needed to elucidate this biphasic change in nitrate seen in this study. The elevated level of plasma nitrate seen after 35 days of voluntary exercise was still present up to 36 h after termination of exercise. We conclude that exercise training in SHR elicits an enhanced formation of NO.

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Citations

Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·B A Kingwell
Nov 6, 2003·Sports Medicine·Andrew MaioranaDaniel Green
Sep 25, 2014·Acta Cirúrgica Brasileira·Renato RochaKleber Eduardo de Campos
Jan 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hong ZhengKaushik P Patel
May 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Masaki MizunoScott A Smith
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B A Kingwell
Jun 19, 2002·Journal of Applied Physiology·Frank W BoothEspen E Spangenburg
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A L Macnair
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R Tatchum-TalomF H Khadour
Feb 10, 1999·The American Journal of Physiology·Q LuJ A Woods
Apr 28, 2012·The Journal of Experimental Biology·Michalis G NikolaidisIoannis S Vrabas

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