Increase in non-tuberculous mycobacteria isolated from humans in Tuscany, Italy, from 2004 to 2014

BMC Infectious Diseases
Laura Rindi, Carlo Garzelli

Abstract

In Italy, the prevalence of non-tuberculous mycobacteria (NTM) in human infections is largely unknown. Herein, we report the epidemiology of NTM infections in a region of central Italy, Tuscany, over the last 11 years, and provide a review of the recent literature on NTM isolation rates in different geographic regions. The complete collection of NTM strains isolated from a total of 42,055 clinical specimens at the Laboratory of Clinical Mycobacteriology of Pisa University Hospital, Italy, from 1 January 2004 to 31 December 2014 was included. In our setting, in the period 2004-2014 a total of 147 patients had cultures positive for NTM. The number of NTM isolates increased considerably from five isolates in 2004 to 29 in 2014; a sharp increase occurred in the last 3 years. Overall, 16 NTM species were isolated; the most common were M. avium, M. intracellulare and M. gordonae detected in respectively in 41.5, 14.3 and 11.6% of NTM patients. In general, NTM isolates were largely prevalent in people older than 60 (57.8%); patients aged 1-10 year-old almost exclusively yielded M. avium and M. intracellulare. Of the 147 NTM clinical isolates, 76.2% were from respiratory specimens, 10.9% from lymph nodes, 2.7% from blood (yielding excl...Continue Reading

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Citations

Aug 5, 2017·American Journal of Respiratory and Critical Care Medicine·Fei ChenPriya Duggal
Jul 11, 2019·Journal of Biophotonics·Cynthia HansonElizabeth Vargis
Jun 18, 2020·International Journal of Molecular Sciences·Laura Rindi
Apr 2, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Melissa MenichiniLaura Rindi
Mar 30, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Hawra Al-Ghafli, Sahal Al-Hajoj
Jun 29, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Eleanor L AxsonJennifer K Quint
Oct 13, 2019·Applied and Environmental Microbiology·Maura J DonohueJoyce M Donohue
Mar 24, 2020·Expert Opinion on Pharmacotherapy·Maria-Carmen Muñoz-EgeaJaime Esteban
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Stefano AlibertiUNKNOWN IRENE Network
Jan 26, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P López-RoaJ Esteban
Jan 19, 2018·Current Opinion in Infectious Diseases·Leah LandeTheodore Plush

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Methods Mentioned

BETA
PCR
bronchoalveolar lavage

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