PMID: 4042707Oct 1, 1985

Increase in PaO2 following intravenous administration of propranolol in acutely hypoxemic patients

Chest
J L VincentE Contu

Abstract

To define the effects of beta-blockade therapy on PaO2, arterial blood gas levels were determined before and after therapeutic administration of propranolol in 44 acutely ill patients. With a FIo2 of 0.33 +/- 0.08, the PaO2 increased from 89.6 +/- 3.6 to 95.3 +/- 3.8 mmHg (p less than 0.01), 10 minutes after intravenous administration of 1 to 3 mg of propranolol. Simultaneous hemodynamic measurements obtained in six patients demonstrated a dramatic decrease in venous admixture, associated with decreases in cardiac output and mixed venous Po2. Propranolol administration generally results in a moderate increase in PaO2, which is related to a significant decrease in pulmonary shunt. The clinical implications of these findings are limited by the expected decrease in tissue oxygen delivery after beta-blockade therapy.

References

Jun 1, 1976·The Journal of Thoracic and Cardiovascular Surgery·R M MentzerS P Nolan
Apr 1, 1979·British Journal of Anaesthesia·J L MarinM K Sykes
Dec 1, 1970·British Journal of Anaesthesia·W E FinlayM K Sykes
Feb 1, 1984·The Journal of Trauma·C L DaviesD G Grahame-Smith
Sep 1, 1983·Journal of Neurosurgery·C S RobertsonR G Grossman
Jun 1, 1980·Anesthesiology·F W Cheney, P S Colley
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss

Citations

Sep 29, 1998·Critical Care Medicine·J L Vincent, J Berre
Apr 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·J L VincentR J Khan
Aug 21, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Natesan Vasanthakumar

Related Concepts

Anoxemia
Diastolic Blood Pressure
Pulse Rate
Hemodynamics
Dioxygen
Rexigen
Pulmonary Circulation
Mechanical Ventilation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.