PMID: 7540279Feb 1, 1995Paper

Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack

Pain
M FanciullacciS Michelacci

Abstract

In this study, changes in plasma levels of calcitonin gene-related peptide (CGRP) and substance P (SP) during a spontaneous-like cluster headache attack provoked by nitroglycerin were evaluated. Peptide variations after spontaneous or sumatriptan-induced remission were also assessed. Blood was collected from the external jugular vein homolateral to the pain side of 30 male cluster headache patients; 18 men were in an active and 12 in a remission one. Plasma levels of CGRP and SP were determined using sensitive radioimmunoassays for each peptide. CGRP-like immunoreactivity (CGRP-LI) was found to be augmented in patients in an active period and became elevated further at the peak of the provoked attack. A complete reversal occurred both after spontaneous and sumatriptan-induced remission. On the contrary, nitroglycerin neither provoked a cluster headache attack nor altered CGRP-LI in the patients in a remission period. The augmented levels of CGRP-LI measured before and after nitroglycerin administration, when the provoked attack reached the maximum intensity, suggest an activation of the trigeminovascular system during the active period of cluster headache. Moreover, the clinical and biochemical actions showed by sumatriptan str...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN Sumatriptan Cluster Headache Study Group
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Feb 26, 1990·Brain Research·P GeppettiF Sicuteri
Apr 1, 1990·Cephalalgia : an International Journal of Headache·A Bogucki
Apr 1, 1990·Cephalalgia : an International Journal of Headache·A DahlK Rootwelt
Aug 1, 1988·Headache·M J Gawel, A Krajewski
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·H SchonS R Bloom
Jan 3, 1985·Nature·S D BrainI MacIntyre
Nov 1, 1968·Archives of Neurology·K Ekbom
Aug 1, 1984·Annals of Neurology·M A Moskowitz
Oct 1, 1984·Neurology·P D Drummond, J W Lance

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Citations

Apr 13, 2001·Microscopy Research and Technique·P J Goadsby
Mar 17, 2001·Current Pain and Headache Reports·A May, P J Goadsby
Mar 17, 2001·Current Pain and Headache Reports·L Edvinsson
Dec 26, 2001·Current Pain and Headache Reports·Sheena K Aurora
May 17, 2011·Current Pain and Headache Reports·Doris Lieba-Samal, Christian Wöber
Mar 9, 2012·Current Pain and Headache Reports·Anna Steinberg, A Ingela M Nilsson Remahl
Sep 14, 2004·Current Pain and Headache Reports·Peter J Goadsby
May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lars NeebUwe Reuter
Aug 23, 2002·Pharmacology & Therapeutics·Paul L Durham, Andrew F Russo
Jun 28, 2000·Progress in Neurobiology·P J Goadsby
Apr 25, 2003·Medical Hypotheses·Yuan Jian Li, Yan Hua Du
Nov 6, 2007·Nature Clinical Practice. Neurology·Peter J Goadsby
Aug 27, 2005·Nature Reviews. Drug Discovery·Peter J Goadsby
Apr 1, 2000·British Journal of Pharmacology·K MesslingerR F Schmidt
Apr 4, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M AshinaJ Olesen
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F KowacsH Kaube
Feb 15, 2002·Cephalalgia : an International Journal of Headache·C SjöstrandJ Hillert
Nov 8, 2002·Cephalalgia : an International Journal of Headache·A I M Nilsson RemahlE Waldenlind
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A May, P J Goadsby
Jul 22, 2004·Cephalalgia : an International Journal of Headache·L Edvinsson
Jan 20, 2004·Cephalalgia : an International Journal of Headache·K EkbomE Waldenlind
Jul 22, 2005·Cephalalgia : an International Journal of Headache·A S Al-DinN Ghaus
Oct 25, 2006·Cephalalgia : an International Journal of Headache·M AlessandriM Fanciullacci
Jul 11, 2013·CNS Drugs·Sarah Vollbracht, Alan M Rapoport
Jul 10, 2003·Lancet Neurology·Peter J Goadsby
May 24, 2001·Current Opinion in Neurology·A May, P J Goadsby

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