Increase in platelet count based on inosine triphosphatase genotype during interferon beta plus ribavirin combination therapy

Journal of Gastroenterology and Hepatology
Hideyuki NomuraMasashi Mizokami

Abstract

The inosine triphosphatase (ITPA) genotype is associated with ribavirin-induced anemia and pegylated interferon α (PEG IFN-α)-induced platelet reduction during PEG IFN-α plus ribavirin combination therapy. Natural IFN-β plus ribavirin therapy is associated with increases in platelet counts during treatment. We investigated decreases in platelet counts according to ITPA genotype during natural IFN-β/ribavirin therapy to determine if patients with low platelet counts were eligible for this combination therapy. A total of 187 patients with chronic hepatitis C received PEG IFN-α/ribavirin or natural IFN-β/ribavirin therapy. Decreases in platelet counts based on ITPA genotype were investigated during treatment through 24 weeks. Platelet counts decreased during week 1 of PEG IFN-α/ribavirin therapy, but increased during week 2, after which platelet counts decreased gradually. Platelet counts decreased until week 4 of natural IFN-β/ribavirin therapy, after which platelet counts increased. Platelet counts after week 8 were higher relative to pretreatment platelet counts. Patients with the ITPA-CC genotype showed a smaller decrease in platelet counts during natural IFN-β/ribavirin therapy than those with the ITPA-CA/AA genotype; platele...Continue Reading

References

Aug 15, 2001·Journal of Human Genetics·Y OhnishiY Nakamura
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 16, 2004·Journal of Gastroenterology and Hepatology·Hideyuki NomuraHiromi Ishibashi
Sep 18, 2009·Nature·David L ThomasMary Carrington
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromitsu KumadaUNKNOWN Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labour and Welf
Sep 17, 2010·World Journal of Gastroenterology : WJG·Mosaburo KainumaUNKNOWN Kyushu University Liver Disease Study Group
Jun 28, 2011·Journal of Hepatology·Alexander J ThompsonAndrew J Muir
Dec 20, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideyuki NomuraSaburo Nishiura

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Citations

Apr 9, 2015·Journal of Clinical Periodontology·Caroline Riben-GrundstromStefan Renvert

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