Abstract
We previously reported a high (˜30%) but stable prevalence of diabetic ketoacidosis (DKA) at youth-onset diagnosis of type 1 diabetes (2002 and 2010). Given the changing demographics of youth-onset type 1 diabetes, we sought to evaluate temporal trends in the prevalence of DKA at diagnosis of type 1 diabetes from 2010 to 2016 among youth <20 years of age and evaluate whether any change observed was associated with changes in sociodemographic distribution of those recently diagnosed. We calculated prevalence of DKA within 1 month of type 1 diabetes diagnosis by year and evaluated trends over time (2010-2016) (n = 7,612 incident diabetes cases; mean [SD] age 10.1 [4.5] at diagnosis). To assess whether trends observed were attributable to the changing distribution of sociodemographic factors among youth with incident type 1 diabetes, we estimated an adjusted relative risk (RR) of DKA in relation to calendar year, adjusting for age, sex, race/ethnicity, income, education, health insurance status, language, season of diagnosis, and SEARCH for Diabetes in Youth Study site. DKA prevalence increased from 35.3% (95% CI 32.2, 38.4) in 2010 to 40.6% (95% CI 37.8, 43.4) in 2016 (P trend = 0.01). Adjustment for sociodemographic factors did ...Continue Reading
References
May 22, 2002·JAMA : the Journal of the American Medical Association·Arleta RewersGeorgeanna Klingensmith
May 3, 2008·Pediatrics·Arleta RewersDana Dabelea
Dec 8, 2009·The Journal of Pediatrics·Helen BuiDenis Daneman
Apr 24, 2010·Diabetes Care·Anne HekkalaUNKNOWN Finnish Pediatric Diabetes Register
Oct 6, 2011·Diabetes Care·Helena Elding LarssonUNKNOWN Finnish Diabetes Registry Study Group
Aug 31, 2012·Diabetologia·J A Usher-SmithF M Walter
Oct 16, 2012·European Journal of Endocrinology·Marco MariglianoClaudio Maffeis
Feb 8, 2013·Diabetologia·S FredheimUNKNOWN Danish Society for Diabetes in Childhood and Adolescence
Jun 14, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·L de VriesM Phillip
Apr 2, 2014·Pediatrics·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study Group
May 24, 2014·Diabetes Care·Fergus J CameronUNKNOWN DKA Brain Injury Study Group
Jul 22, 2014·Pediatric Diabetes·Joseph I WolfsdorfRagnar Hanas
Nov 22, 2014·Diabetes Care·Richard F HammanUNKNOWN SEARCH for Diabetes in Youth Study Group
Apr 22, 2015·JAMA : the Journal of the American Medical Association·Arleta RewersMarian Rewers
Aug 19, 2015·Diabetes Care·David M MaahsReinhard W Holl
Dec 15, 2015·Journal of Diabetes·Larry A FoxUNKNOWN T1D Exchange Clinic Network
Jul 12, 2016·Diabetologia·Fraser W GibbK Ann Lockman
Jul 17, 2016·Diabetes Care·James A MaysAmisha Wallia
Aug 18, 2016·JAMA Internal Medicine·Benjamin D SommersArnold M Epstein
Mar 17, 2017·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Christopher A TaylorLikang Xu
May 26, 2017·Pediatric Diabetes·Anne M HekkalaRiitta Veijola
Mar 10, 2018·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Johann GroßeUlrike Rothe
Mar 30, 2018·MMWR. Morbidity and Mortality Weekly Report·Stephen R BenoitAnn Albright
Apr 11, 2018·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Meranda NakhlaPatricia Li
May 19, 2018·Diabetes Care·Dimpi DesaiUlrich K Schubart
Dec 18, 2018·Pediatric Diabetes·Lindsey M DucaDana Dabelea
Dec 24, 2018·Diabetes Care·Tandy AyeUNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Apr 16, 2019·JAMA : the Journal of the American Medical Association·Edward W GreggStephen R Benoit
May 16, 2019·CMAJ Open·Marie-Eve RobinsonMeranda M Nakhla
Jun 21, 2019·PloS One·Ulf ManuwaldUlrike Rothe
Oct 3, 2019·Diabetes Care·Sharon H SaydahGiuseppina Imperatore
Oct 12, 2019·Diabetes Care·G Todd AlonsoArleta Rewers
Jan 29, 2020·JAMA : the Journal of the American Medical Association·Anette-Gabriele ZieglerUNKNOWN Fr1da Study Group
May 10, 2020·Diabetologia·Valentino CherubiniDana Dabelea
May 16, 2020·Nature Reviews. Disease Primers·Ketan K DhatariyaGuillermo E Umpierrez