Abstract
Monitoring of primary drug resistance is of interest for long-term evaluation of the efficacy of a national tuberculosis program. The objective was to describe changes over time in primary drug resistance among new tuberculosis patients. Stratified analysis by birth cohorts, region of birth, HIV-coinfection of data from 14,610 culture-positive new tuberculosis patients diagnosed by a network of university hospitals between 1995 and 2008. Half of the patients were foreign-born, and 9% HIV-coinfected. For foreign-born and French-born patients, there was an upward trend in resistance rates to streptomycin, isoniazid, and rifampicin from the oldest to the youngest cohorts. For a same age at tuberculosis diagnosis, the risk of isoniazid resistance was higher in younger cohorts, revealing a cohort effect. Among French-born patients, the only factor independently associated with primary resistance to streptomycin, or isoniazid was birth after 1950, and particularly after 1980. Risk of streptomycin resistance increased in youngest cohorts among European-born patients. HIV-coinfection was associated to rifampicin resistance among foreign-born and French-born patients, Theses results indicate that among French-born patients, isoniazid-re...Continue Reading
References
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·R RidzonI M Onorato
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine
Jan 22, 2002·Journal of Medical Microbiology·Leonid Heifets
Oct 11, 2003·BMJ : British Medical Journal·Dermot MaherMario Raviglione
Nov 19, 2003·The European Respiratory Journal·J RobertV Jarlier
Jun 24, 2004·Revue des maladies respiratoires·UNKNOWN Société de Pneumologie de Langue Française
Sep 4, 2004·Revue des maladies respiratoires·B DautzenbergJ-P Grignet
May 18, 2006·Emerging Infectious Diseases·Maria Elvira BalcellsAlison D Grant
Jun 15, 2007·The European Respiratory Journal·P M KhuêJ Robert
May 6, 2008·BMJ : British Medical Journal·Michelle E KruijshaarIbrahim Abubakar
Oct 15, 2008·Archives of Internal Medicine·Andrea J HoopesLori R Armstrong
Dec 18, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adithya CattamanchiPayam Nahid
Mar 12, 2011·Emerging Infectious Diseases·Christopher VinnardGregory P Bisson
Apr 16, 2014·AIDS Care·Kayigan d'Almeida WilsonUNKNOWN ANRS-Vespa2 Study Group
Citations
Jul 3, 2013·Médecine et maladies infectieuses·E HonnoratUNKNOWN le comité de pilotage et groupe des investigateurs
Jan 15, 2014·BMC Infectious Diseases·Vanina MeyssonnierJérôme Robert
Aug 10, 2016·ELife·Vegard EldholmFrancois Balloux
Sep 29, 2017·PloS One·Ana Maria TavaresSónia Dias
Mar 14, 2014·The Pediatric Infectious Disease Journal·Begoña SantiagoUNKNOWN EREMITA Study Group
Apr 7, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marwa BachirUNKNOWN Isoniazid Resistance Group