Increase in response and number of alpha-adrenoceptors of rat vas deferens on brief pretreatment with an alpha-agonist

European Journal of Pharmacology
F HataH Yoshida

Abstract

The contractile response of rat vas deferens to epinephrine (E) was enhanced by preincubation with E. After pretreatment with E, there was no significant change in the ED50 of E but there was a significant increase in the maximum response (39%). There was no change in the cholinergic response after the pretreatment. alpha-Adrenoceptors in control and E-treated tissues were assessed by measuring [3H]WB-4101 binding. Treatment with E resulted in a 27% increase in the number of alpha-adrenoceptors, but no change in muscarinic acetylcholine receptors measured with [3H]quinuclidinyl benzilate. These results are discussed in relation to the response of alpha-adrenoceptors to the agonist.

References

Sep 23, 1977·Biochemical and Biophysical Research Communications·G Glaubiger, R J Lefkowitz

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Citations

Jun 3, 1983·European Journal of Pharmacology·M BaudryG Lynch
Sep 3, 1984·European Journal of Pharmacology·F HataH Ishida
Jan 2, 1985·European Journal of Pharmacology·F HataH Ishida
Jan 1, 1983·British Journal of Clinical Pharmacology·J M Gaillard

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