Increase in serum mitochondrial creatine kinase levels induced by tenofovir administration

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Dai WatanabeTakuma Shirasaka

Abstract

Recently, 2 monoclonal antibodies that specifically inhibit mitochondrial creatine kinase (MtCK) activity have been developed. In this study, we measured the serum MtCK activity in HIV-1-infected individuals (n = 100) by employing a novel method using these antibodies. The mean serum MtCK activity in 44 patients treated with highly active antiretroviral therapy (HAART) including tenofovir disoproxil fumarate (TDF) was 16.0 IU/L. The MtCK activity was significantly higher in patients receiving TDF than in those receiving HAART without TDF (3.4 IU/L) or in naïve patients (6.9 IU/L) (Tukey-Kramer test, p < 0.0001 and p = 0.0029, respectively). The serum MtCK activity reached a plateau at 1 month after the initiation of TDF administration and decreased upon discontinuation. It showed no significant correlation with the trough plasma TDF concentration, serum creatinine level, or red blood cell count. The activity was elevated in 75% of the patients receiving TDF, and this elevation was specific to TDF; it was not observed with other anti-HIV drugs. In addition, our report emphasizes the careful interpretation of creatine kinase-MB (CK-MB) test results in patients receiving TDF because MtCK in serum could cause false-positive results...Continue Reading

References

Apr 13, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·F KanemitsuT Okigaki
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M StadhoudersT Wallimann
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Russell FleischerKenneth E Sherman
Aug 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grace McComsey, J Tyler Lonergan
Oct 21, 2005·Biochimica Et Biophysica Acta·Uwe SchlattnerTheo Wallimann
Dec 20, 2007·American Journal of Therapeutics·Toshio MakieTakeshi Kuwahara
Jan 4, 2008·The Journal of Infectious Diseases·Miguel GoicoecheaUNKNOWN California Collaborative Treatment Group 578 Team
Mar 11, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·James J KohlerWilliam Lewis
Apr 14, 2009·AIDS Research and Human Retroviruses·Ei Kinai, Hideji Hanabusa
Jul 8, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dirk LebrechtUlrich A Walker

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