PMID: 9542590May 30, 1998Paper

Increase in SNAP-25 immunoreactivity in the mossy fibers following transient forebrain ischemia in the gerbil

Acta Neuropathologica
E MartíJ Blasi

Abstract

SNAP-25 (a synaptosomal-associated protein of 25 kDa) has been shown to be involved both in synaptic vesicle exocytosis and in axonal outgrowth. In the present study, we investigated the changes in SNAP-25 immunoreactivity in the hippocampus of the Mongolian gerbil (Meriones unguiculatus) at different time points after transient forebrain ischemia insult. In parallel, immunostaining for GAP-43, a protein involved in axonal outgrowth, and for syntaxin-1 (stx1A and stx1B), another protein implicated in neurotransmitter release, was also analyzed. The animals were subjected to 2.5 or 5 min of transient forebrain ischemia through bilateral common carotid occlusion, and examined at different intervals after ischemia. SNAP-25 immunoreactivity was increased in the mossy fiber layer as early as 2 days after 5 min of ischemia. Increased SNAP-25 immunoreactivity in mossy fibers was also detected at days 4 and 7 after ischemia. On day 15, SNAP-25 staining was similar to that observed in control non-ischemic animals. In contrast, no changes in GAP-43 and syntaxin-1 immunoreactivity were observed in the mossy fiber layer following 5 min of ischemia. No modifications in SNAP-25, syntaxin-1 or GAP-43 immunoreactivity were observed following 2...Continue Reading

Citations

Jul 12, 2002·Journal of Neuroscience Research·Neelima B Chauhan, George J Siegel
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E GoutanI Ferrer
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H NishimuraM Okamoto
May 28, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Su Jin ParkKyung Eun Lee
Nov 23, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·N MitsiosM Slevin
Aug 30, 2014·Behavioural Pharmacology·Francisco Diego Pinheiro FernandesGeanne Matos de Andrade
Jan 16, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Prabal DebK M Hassan

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