PMID: 9188618Jul 1, 1997Paper

Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair

Journal of Virology
J PetersenC E Rogler

Abstract

Persistent hepadnavirus infection leads to oxidative stress and DNA damage through increased production of toxic oxygen radicals. In addition, hepadnaviral DNA integrations into chromosomal DNA can promote the process of hepatocarcinogenesis (M. Feitelson, Clin. Microbiol. Rev. 5:275-301, 1992). While previous studies have identified preferred integration sites in hepadnaviral genomes and suggested integration mechanisms (M. A. Buendia, Adv. Cancer Res. 59:167-226, 1992; C. E. Rogler, Curr. Top. Microbiol. Immunol. 168:103-141, 1991; C. Shih et al., J. Virol. 61:3491-3498, 1987), very little is known about the effects of agents which damage chromosomal DNA on the frequency of hepadnaviral DNA integrations. Using a recently developed subcloning approach to detect stable new integrations of duck hepatitis B virus (DHBV) (S. S. Gong, A. D. Jensen, and C. E. Rogler, J. Virol. 70:2000-2007, 1996), we tested the effects of increased chromosomal DNA damage induced by H2O2, or of the disturbance in DNA repair due to the inhibition of poly(ADP-ribose) polymerase (PARP), on the frequency of DHBV DNA integrations. Subclones of LMH-D21-6 cells, which replicate DHBV, were grown in the presence of various H2O2 concentrations and exhibited up...Continue Reading

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Citations

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J PetersenC E Rogler
Jan 21, 2006·World Journal of Gastroenterology : WJG·Gerald C KimbiMichael C Kew
Dec 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jesse Summers, William S Mason
Sep 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Raina T GaySimin Nikbin Meydani
Jul 29, 2004·Journal of Virology·Jun YoshitakeHiroshi Maeda
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maura Dandri, Jorg Petersen
Dec 15, 2016·Oncotarget·Alexander V IvanovMaria G Isaguliants
Sep 25, 1999·Journal of Cellular Physiology·M A Feitelson
Jul 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Colin A Bill, Jesse Summers
Jun 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaowen HuYujia Xia
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maura DandriJoerg Petersen
Nov 6, 2020·Scientific Reports·Meghri KaterjiPenelope J Duerksen-Hughes
Mar 4, 2021·Viruses·Teresa Pollicino, Giuseppe Caminiti
Jan 17, 2019·Oxidative Medicine and Cellular Longevity·Zaib Ur RehmanChan Ding
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Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M DandriJ Petersen
Nov 29, 2005·Nitric Oxide : Biology and Chemistry·Teruo AkutaTakaaki Akaike

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