PMID: 6978592Feb 1, 1982Paper

Increase in the penetration of tracer compounds into the rat brain during 2-methyl-4-chlorophenoxyacetic acid (MCPA) intoxication

Acta Pharmacologica Et Toxicologica
H A EloH Hervonen

Abstract

The penetration of different intravenous tracer molecules such as 14C-labelled 2-methyl-4-chlorophenoxyacetic acid (14C-MCPA), 14C-p-aminobenzoic acid (14C-PABA), 14C-sucrose, 14C-antipyrine and iodinated (125I) human albumin (125I-HA) into the brain and cerebrospinal fluid (CSF) was studied in MCPA-intoxicated and control rats. Toxic subcutaneous doses of sodium salt of MCPA (200-500 mg/kg) increased highly the brain/plasma and CSF/plasma ratios of 14C-MCPA and 14C-PABA, as compared to the muscle/plasma ratio. Probenecid (200 mg/kg) did not affect the cerebral MCPA concentration in the intoxicated animals. The tissue/plasma ratios of 14C-sucrose, 14C-antipyrine and 125I-HA were also increased in the brain and CSF of intoxicated animals, but the increases were less pronounced than those of 14C-MCPA or 14C-PABA. The results indicate that MCPA intoxication caused a selective damage of the blood-brain barrier in the brain areas studied.

References

Jan 1, 1976·Acta Anaesthesiologica Scandinavica·P YlitaloL Ahtee
Nov 1, 1973·The Journal of Comparative Neurology·E Westergaard, M W Brightman
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Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Jan 1, 1962·Archives of Environmental Health·I DESIV MARKUS

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Citations

Apr 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I Walker, M D Coleman
Aug 30, 2005·Annals of Emergency Medicine·Darren M RobertsMichael Eddleston
Oct 1, 1986·Environmental Research·N Pacces ZaffaroniE Arias

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