PMID: 7521809Sep 1, 1994Paper

Increase in the proportion of granulated CD56+ T cells in patients with malignancy

Clinical and Experimental Immunology
Y TakiiT Abo

Abstract

Evidence is presented for the existence of a unique T cell population which expressed one of the natural killer (NK) markers, CD56 antigen, in humans. Although such CD56+ T cells were a minor population in the peripheral blood (< 10%), they were abundant in the liver (up to 50%), which was recently demonstrated to be a major organ for extrathymic T cell differentiation in mice. As in the case of extrathymic T cells in mice, these CD56+ T cells in humans contained a higher proportion of gamma delta T cells than did CD56- T cells, contained double-negative CD4-8- cells, and had the morphology of large granular lymphocytes. This unique population of CD56+ T cells tended to be elevated in the blood and among tumour-infiltrating lymphocytes in patients with colorectal cancer, especially in advanced cases. These results raise the possibility that, as in mice, CD56+ T cells with extrathymic T cell properties may also be associated with tumour immunity in humans.

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Citations

Jul 9, 2002·Clinical and Experimental Immunology·T IiaiK Hatakeyama
Mar 8, 2002·Clinical and Experimental Immunology·S J C GolbyJ Spencer
Mar 1, 2002·Immunology and Cell Biology·Lucy Golden-Mason, Cliona O'Farrelly
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·Kamal U SaikhRobert G Ulrich
Feb 12, 2013·Cell and Tissue Research·Magdalena Dutsch-WicherekLukasz Wicherek
Apr 1, 1996·Diseases of the Colon and Rectum·A EspíS Lledó
Aug 26, 1998·Clinical and Experimental Immunology·N MushaT Abo
Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Magdalena Dutsch-WicherekRomana Tomaszewska
Mar 17, 2010·International Journal of Clinical Oncology·Junji Akagi, Hideo Baba
May 18, 2012·Journal of Leukocyte Biology·Wei HouWen-Zhe Ho
Oct 1, 1995·Clinical and Experimental Immunology·T OkadaT Abo
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Golden-MasonC O'Farrelly
Aug 10, 2000·Clinical and Experimental Immunology·H OyaT Abo
Dec 19, 2008·International Journal of Clinical Oncology·Junji Akagi, Hideo Baba
Jan 10, 2017·Frontiers in Immunology·María Luisa Pita-LópezRafael Solana
Mar 26, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Kenichi HaradaYasuni Nakanuma

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