PMID: 8944612Nov 1, 1996Paper

Increase in the relative level of type V collagen during development and ageing of the placenta

Journal of Clinical Pathology
M IwahashiR Nakano

Abstract

To obtain some insight into the extracellular matrix in the placenta, changes in the composition of collagens during placental development were investigated. Collagen was extracted from placentas (group 1, 25-30 weeks, n = 21; group 2, 31-36 weeks, n = 32; and group 3, 37-41 weeks of gestation, n = 40) and the relative concentrations of various collagens were evaluated by SDS-PAGE. The ratio of the intensity of the alpha 1 (III) band to that of alpha 1 (I) chain collagen in group 3 placentas were lower than those in group 1 placentas. In contrast, the ratio of the intensity of the alpha 1 (V) band to that of alpha 1 (I) chain collagen in group 3 placentas were higher than those in group 1 and group 2 placentas. These results suggest that type V collagen might play an important role in the function of the placenta and that an increased relative concentration of type V collagen might be closely associated with the development and ageing of the placenta.

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Citations

Sep 22, 2006·Connective Tissue Research·Tumurbaatar BatbayalShinji Nakamura
Jan 12, 2016·Bulletin of Experimental Biology and Medicine·E V AleginaA E Donnikov
Feb 16, 2008·Acta histochemica·Leyla SatiRamazan Demir
Jun 20, 2014·International Journal of Experimental Pathology·Dora FabijanovicLjiljana Serman
Jul 24, 2002·Biology of Reproduction·Antonin BukovskyRobert F Elder
Jul 20, 2006·Microbiology·Rishi D PathiranaEric C Reynolds

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