Increase in thyroid stimulating hormone levels in patients with gout treated with inhibitors of xanthine oxidoreductase

Rheumatology International
Fernando Perez-RuizMaria Angeles Aniel-Quiroga

Abstract

Increase in thyroid stimulating hormone (TSH) levels over the upper normal limit has been reported in a small percentage of patients treated with febuxostat in clinical trials, but a mechanistic explanation is not yet available. In an observational parallel longitudinal cohort study, we evaluated changes in TSH levels in patients with gout at baseline and during urate-lowering treatment with febuxostat. Patients to be started on allopurinol who had a measurement of TSH in the 6-month period prior to baseline evaluation were used for comparison. TSH levels and change in TSH levels at 12-month follow-up were compared between groups. Patients with abnormal TSH levels or previous thyroid disease or on amiodarone were not included for analysis. Eighty-eight patients treated with febuxostat and 87 with allopurinol were available for comparisons. Patients to be treated with febuxostat had higher urate levels and TSH levels, more severe gout, and poorer renal function, but were similar regarding other characteristics. A similar rise in TSH levels was observed in both groups (0.4 and 0.5 µUI/mL for febuxostat and allopurinol, respectively); at 12-mo, 7/88 (7.9 %) of patients on febuxostat and 4/87 (3.4 %) of patients on allopurinol show...Continue Reading

References

Sep 1, 1994·The American Journal of Medicine·A R EricksonJ A Merenich
Dec 2, 2004·Nucleosides, Nucleotides & Nucleic Acids·S HoshideT Hosoya
Dec 17, 2005·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Fernando Perez-RuizJoan M Nolla
Jul 28, 2007·Clinical Pharmacokinetics·Richard O DayKenneth M Williams
Nov 28, 2009·Journal of Endocrinological Investigation·O MakayE Yetkin
Sep 8, 2011·Arthritis and Rheumatism·Fernando Perez-RuizLoreto Carmona

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Citations

Mar 5, 2016·Expert Review of Clinical Pharmacology·Sandra P ChinchillaFernando Perez-Ruiz
Oct 19, 2016·Clinical Pharmacokinetics·Bishoy KamelRichard O Day

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