PMID: 8947305Nov 1, 1996Paper

Increase in vasoactive prostaglandin E production after perfusion in human placental cotyledons

Alcoholism, Clinical and Experimental Research
C L RandallJ L Cook

Abstract

Studies from our laboratory indicate that prostaglandins may be mediators of at least some of the teratogenic actions of ethanol in both mouse and human tissue model systems. The present studies were designed to evaluate the relationship between ethanol and prostaglandin E (PGE) production in isolated human placental cotyledons. Placentas were obtained immediately after cesarean section delivery. A fetal artery supplying a single cotyledon was identified and cannulated, and the isolated cotyledon was placed in a perfusion chamber where maternal circulation was established and dual circulation continued throughout the perfusion procedure. Antipyrine clearance, oxygen consumption, and placental production of human chorionic gonadotropin were measured to verify tissue viability. PGE levels of the perfusate were measured by radioimmunoassay. Study 1 evaluates the effect of perfusion with 25 and 100 mM ethanol on placental PGE production. It was found that PGE production increased after perfusion with 25 mM ethanol, but not during the perfusion period per se. The paradigm for study 2 was identical to that of study 1, with the addition of a buffer washout period after 100-mM ethanol perfusion. Again, results indicate that perfusate P...Continue Reading

References

Sep 15, 1976·American Journal of Obstetrics and Gynecology·J C ChallierJ Dancis
Jun 1, 1992·Clinical Obstetrics and Gynecology·G G Zeeman, G A Dekker
Feb 1, 1991·American Journal of Obstetrics and Gynecology·L MyattD E Brockman
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·C L RandallR F Anton
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Dec 1, 1988·Prostaglandins·R F AntonH C Becker
Jun 1, 1986·Canadian Journal of Physiology and Pharmacology·F CoceaniP M Olley
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·T V Persaud
Nov 1, 1985·Prostaglandins, Leukotrienes, and Medicine·J W KaranianN Salem
May 1, 1985·Toxicology and Applied Pharmacology·N H DubinM C DiBlasi
Mar 1, 1973·Prostaglandins·T V Persaud
Sep 1, 1973·Prostaglandins·T V PersaudK L Moore
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·G I HendersonS Schenker
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·S N PenningtonJ L Morgan
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·G I HendersonS Schenker
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·C L Randall, J L Saulnier
Aug 3, 1994·European Journal of Pharmacology·S M TaylorT H Florin
Apr 1, 1995·Mutation Research·S D DertingerA M Tometsko

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Citations

Dec 11, 1999·Alcoholism, Clinical and Experimental Research·J L CookD M Olson
Apr 4, 2007·Alcoholism, Clinical and Experimental Research·Robert J SokolJoseph L Jacobson
Dec 24, 2003·Addiction Biology·Marcelo LopezCarrie Randall
May 9, 2001·Addiction Biology·Marcelo F. LopezCarrie L. Randall
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Larry BurdHein Odendaal
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L CookS T Davidge
Dec 15, 2010·Alcoholism, Clinical and Experimental Research·Pradeep K ShuklaEva E Redei
May 13, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J L Cook, C L Randall

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