PMID: 2494759Feb 1, 1989Paper

Increase in ventilation caused by aminophylline in the absence of changes in ventral medullary extracellular fluid pH and carbon dioxide tension

Thorax
S JavaheriL J Teppema

Abstract

A study was designed to investigate the possibility that changes in ventral medullary extracellular fluid carbon dioxide tension (PCO2) and hydrogen ion (H+) concentration mediate the ventilatory stimulation induced by systemic administration of aminophylline. Six cats with peripheral chemodenervation (bilateral carotid sinus nerve and vagal neurotomy) were studied while anaesthetised with chloralose urethane and breathing spontaneously at a regulated, constant, and somewhat raised end tidal PCO2. Variables were measured during steady state normoxaemia and 10 and 30 minutes after administration of 17 mg/kg aminophylline (mean (SD) blood concentration of theophylline 14.2 (1.5) mg/l). Aminophylline resulted in a significant and considerable increase in minute ventilation to 155% and 167% above baseline at 10 and 30 minutes. Mean (SD) values for arterial PCO2 were 5.6 (0.6), 5.6 (0.6), and 5.4 (0.6) kPa at 0, 10, and 30 minutes. Values for the ventral medullary extracellular fluid PCO2 were 7.6 (1.1), 7.5 (1.0), and 7.4 (1.0) kPa and for H+ concentration 62.7 (9.3), 62.6 (9.3), and 63.5 (8.0) nmol/l at 0, 10, and 30 minutes. After aminophylline infusion the PCO2 and H+ concentration of the extracellular fluid did not differ signi...Continue Reading

References

Jan 1, 1975·European Journal of Pharmacology·J W PhillisJ J Limacher
Oct 1, 1987·Journal of Applied Physiology·S Javaheri, L J Teppema
May 1, 1988·Journal of Applied Physiology·S JavaheriJ A Evers
Nov 1, 1985·Journal of Applied Physiology·F L EldridgeJ P Kiley
Sep 1, 1972·Stroke; a Journal of Cerebral Circulation·U Gottstein, O B Paulson
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H SnyderJ W Daly
Aug 1, 1983·Respiration Physiology·F L EldridgeJ P Kiley
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S JavaheriJ S Brody
Jan 1, 1950·The Journal of Clinical Investigation·R L WECHSLERS S KETY

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Citations

Jul 12, 2005·Current Treatment Options in Cardiovascular Medicine·Shahrokh Javaheri, Laura Wexler
Sep 11, 2008·Current Treatment Options in Neurology·Shahrokh Javaheri
Jun 13, 2003·Clinics in Chest Medicine·Shahrokh Javaheri
Aug 22, 1996·The New England Journal of Medicine·S JavaheriG A Roselle
Feb 4, 2006·Current Opinion in Pulmonary Medicine·Felix S F Ram
Jun 24, 2004·Drugs·Ian E Smith, Timothy G Quinnell
Mar 1, 1992·Chest·E Mulloy, W T McNicholas
Oct 3, 1999·Experimental Neurology·D W Carley, M Radulovacki
Jan 10, 2003·The Cochrane Database of Systematic Reviews·F S RamS Cendon

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