Increase in waist circumference over 6 years predicts subsequent cardiovascular disease and total mortality in nordic women

Obesity
Sofia KlingbergL Lissner

Abstract

Despite solid evidence of an association between centralized body fatness and subsequent disease risk, little is known about the consequences of changes in body fat distribution. Recently it was shown that large hip circumference (HC), measured once, was protective against total and cardiovascular disease (CVD) mortality in women but that gain or loss in HC was unrelated to these outcomes. This study examines whether a 6-year change in waist circumference (WC) predicts mortality and CVD in the same study sample. Baseline WC and 6-year change in WC as predictors of mortality and CVD were analyzed in 2,492 women from the Danish MONICA study and the Prospective Population Study of Women in Gothenburg, Sweden. Increase in WC was significantly associated with increased subsequent mortality and CVD adjusting for BMI and other covariates, with some evidence of a J-shaped association. Associations between increase in WC and outcomes were restricted to women with normal weight at baseline and to ever-smokers. In contrast to changes in HC which did not predict mortality and CVD, a 6-year increase in WC is strongly predictive, particularly among initially lean women and ever-smokers. This implies the importance of developing strategies to...Continue Reading

References

Mar 1, 1991·Gastroenterology·K H Jensen, T Jørgensen
Nov 1, 1987·American Journal of Epidemiology·T Jørgensen
Oct 10, 1997·The American Journal of Clinical Nutrition·C G Solomon, J E Manson
Apr 27, 2002·The American Journal of Clinical Nutrition·Berit Lilienthal Heitmann, Lars Garby
Dec 15, 2006·Nature·Luc F Van GaalChristophe E De Block
Jan 9, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T B Chaston, J B Dixon
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Apr 29, 2009·International Journal of Cardiology·Kyriakoula MarinouChristodoulos Stefanadis
Dec 22, 2009·Maturitas·Birgit TeucherRudolf Kaaks
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle D HolmesSusan E Hankinson
Oct 12, 2010·PloS One·Tina Landsvig BerentzenThorkild I A Sørensen
Oct 18, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A J CameronS Söderberg
Nov 22, 2012·Journal of the American Medical Directors Association·Ellen L de HollanderLisette C P G M de Groot
Jul 31, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A K CohenB Abrams
Feb 18, 2014·Current Obesity Reports·Maria MagnussonLauren Lissner
Dec 9, 2014·Obesity Facts·John E BlundellUNKNOWN EASO SAB Working Group on BMI

❮ Previous
Next ❯

Citations

Sep 19, 2019·Journal of Women's Health·Stephen W FarrellWilliam L Haskell
Nov 20, 2016·International Journal of Epidemiology·Amalia KarahaliosJulie A Simpson
Aug 14, 2020·International Journal of Environmental Research and Public Health·Jennifer HarganDalia Malkova
Jun 23, 2021·Alimentary Pharmacology & Therapeutics·Rong FanUNKNOWN Chronic Hepatitis B Study Consortium

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.