Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm

Scientific Reports
Ren-Wen HoMing-Tse Kuo

Abstract

The aim of this study was to investigate changes in the tear film lipid layer thickness (LLT) and aqueous tear production after botulinum neurotoxin A (BoNT) injection in patients with benign essential blepharospasm (BEB) and hemifacial spasm (HFS). Eleven and six patients with BEB and HFS, respectively, who received BoNT injection were consecutively enrolled in this prospective study. The blepharospasm disability index (BSDI), blink pattern, dry eye symptoms, Schirmer test 1 findings, LLT, eyelid performance, and corneal integrity were evaluated before and after treatment. Both BEB and HSF patients experienced remarkable relief from spasms and ocular discomfort after BoNT injection. LLT, the partial blink rate, the snap-back time, the lid distraction distance, and lateral canthal laxity were significantly increased at 1 month after treatment. There were no significant changes in Schirmer test 1 findings and meibomian gland dropout. Our findings suggest that LLT, a decisive factor for tear film stability, significantly increases at 1 month after BoNT injection for BEB and HFS. A decrease in BSDI and an increase in the snap-back time may contribute to the increase in LLT; this mechanism is probably responsible for the relief fro...Continue Reading

References

Jul 1, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·S JitpimolmardM Laopaiboon
Apr 15, 2000·American Journal of Ophthalmology·S SahlinG Lennerstrand
Mar 14, 2002·Archives of Neurology·Giovanni DefazioAlfredo Berardelli
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·G-Y R HsiungO Suchowersky
Apr 27, 2004·Experimental Eye Research·A J BronL W Voon
Jun 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Jan 13, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Nicte I MejiaJoseph Jankovic
Aug 23, 2005·Journal of the American Academy of Dermatology·Timothy R CotéM Miles Braun
Sep 20, 2005·Orbit·Krishnamoorthy Narayanan, Eric A Barnes
Jan 11, 2007·Survey of Ophthalmology·Jonathan J Dutton, Amy M Fowler
Jan 12, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Donna PageMarjan Jahanshahi
Jun 15, 2007·Journal of Neural Transmission·C Kenney, J Jankovic
May 6, 2008·Developments in Ophthalmology·Sven Sahlin, Rikard Linderoth
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Oct 31, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Heiko Pult, Britta Riede-Pult
Feb 26, 2013·Journal of Neural Transmission·Daniel D TruongUNKNOWN Xeomin US Blepharospasm Study Group
Apr 2, 2013·American Journal of Ophthalmology·Craig N CzyzJill A Foster
Jul 13, 2013·Clinical & Experimental Ophthalmology·Osama H AbabnehDwight R Kulwin
May 8, 2014·European Journal of Ophthalmology·Sibel KocabeyogluAli Sefik Sanac
Jun 26, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Gina FerrazzanoAlfredo Berardelli
Jul 21, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pam SatjawatcharaphongMeng C Lin
Jun 29, 2016·Acta Ophthalmologica·Juan Carlos Serna-Ojeda, Angel Nava-Castaneda
Aug 16, 2016·PloS One·Jing YangHui-Fang Shang

❮ Previous
Next ❯

Citations

May 7, 2021·Clinical Ophthalmology·Supharat JariyakosolYuda Chongpison
May 3, 2021·Survey of Ophthalmology·Sonali T NagendranRaman Malhotra

❮ Previous
Next ❯

Methods Mentioned

BETA
BSDI

Software Mentioned

power
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.