PMID: 2503043Aug 18, 1989Paper

Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs

Biochimica Et Biophysica Acta
R C Harab, P A Mourão

Abstract

The absolute concentrations of chondroitin 4- and 6-sulfate are compared in articular and endochondral ossification cartilage from normal dogs. In newborn dogs, the absolute concentration of chondroitin 4-sulfate decreases nearly 3-fold from the deeper endochondral ossification cartilage to the articular surface, whereas that of chondroitin 6-sulfate does not change. In cartilage from the articular surface of the epiphysis in adults, where the ossification process is complete, the concentration of chondroitin 4-sulfate is also low. These observations suggest that chondroitin 4-sulfate may be important in the ossification process. The pathogenesis of heritable disorders involving the sulfation of chondroitin sulfate is discussed in view of these findings.

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Sep 7, 2011·Glycoconjugate Journal·Peraphan PothacharoenPrachya Kongtawelert
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Dec 6, 2006·The Journal of Veterinary Medical Science·Hiroaki KamishinaElizabeth W Uhl

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