PMID: 9523567Apr 2, 1998Paper

Increase of extracellular glutamate and expression of Fos-like immunoreactivity in the ventral tegmental area in response to electrical stimulation of the prefrontal cortex

Journal of Neurochemistry
Z L RossettiR A Wise

Abstract

Electrical stimulation of the medial prefrontal cortex caused glutamate release in the ventral tegmental area (VTA) of freely moving animals. Cathodal stimulation was given through monopolar electrodes in 0.1-ms pulses at an intensity of 300 microA and frequencies of 4-120 Hz. Glutamate was measured in 10-min perfusate samples by HPLC coupled with fluorescence detection following precolumn derivatization with o-phthaldialdehyde/beta-mercaptoethanol. The stimulation-induced glutamate release was frequency dependent and was blocked by the infusion of the sodium channel blocker tetrodotoxin (10 microM) through the dialysis probe. The stimulation also induced bilateral Fos-like immunoreactivity in ventral tegmental neurons, with a significantly greater number of Fos-positive cells on the stimulated side. These findings add to a growing body of evidence suggesting that the medial prefrontal cortex regulates dopamine release in the nucleus accumbens via its projection to dopamine cell bodies in the VTA.

Citations

Feb 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel J Lodge
Feb 26, 1999·Journal of Neurochemistry·F M Inglis, B Moghaddam
Apr 6, 2017·The European Journal of Neuroscience·J AguirreM Caba
Sep 15, 2018·Behavioural Pharmacology·Zahra BahariMohammad A Meftahi
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T P ObrenovitchT M Jay
Jun 4, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nathan S PentkowskiJanet L Neisewander
Apr 27, 2013·The European Journal of Neuroscience·Ricardo M BaltazarIan C Webb
Nov 6, 2018·Psychopharmacology·Wen-Hua ZhangYan-Xue Xue

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