Increase of follicular helper T cells skewed toward a Th1 profile in CVID patients with non-infectious clinical complications

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Delphine TurpinDorothée Duluc

Abstract

Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins and defects in B cell maturation leading to an increased susceptibility to infections. Some patients develop complications such as autoimmune diseases, enteropathy, and lymphoproliferation, resulting in higher morbidity and mortality. Follicular helper T (Tfh) cells are specialized in helping B cell differentiation into Ig-producing cells. Three subsets have been described, namely non B-cell helper Tfh1 and the two B-helper cell subsets Tfh2 and Tfh17. We determined that circulating Tfh cells were elevated in CVID patients and skewed toward a Tfh1 profile. Interestingly, elevated levels of Tfh1 cells were significant only in patients harboring non-infectious complications regardless of the type of complication and inversely correlated with switched memory B cells. Moreover, CXCR3+ cells are increased in splenic CVID germinal centers. Our observations suggest that the altered balance in Tfh subsets in CVID is linked to a more severe disease.

Citations

May 16, 2019·Journal of Clinical Immunology·Yannick DieudonnéAnne-Sophie Korganow
May 14, 2019·Clinical and Molecular Allergy : CMA·Antonio PecoraroGiuseppe Spadaro
Feb 23, 2020·Frontiers in Immunology·Corentin Le Saos-PatrinosDorothée Duluc
Mar 19, 2020·Frontiers in Immunology·Antonio PecoraroGiuseppe Spadaro
Oct 8, 2020·World Journal of Clinical Cases·Ewa Więsik-Szewczyk, Karina Jahnz-Różyk
Feb 23, 2021·Frontiers in Immunology·Erik M MatsonPaul J Maglione
Mar 16, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Theodore K LeePaul J Maglione
Jun 20, 2021·The Journal of Allergy and Clinical Immunology·Miranda L AbyaziPaul J Maglione

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