Increase of frontal neuronal activity in chronic neglect after training in virtual reality

Acta Neurologica Scandinavica
U EkmanJan Malm

Abstract

A third of patients with stroke acquire spatial neglect associated with poor rehabilitation outcome. New effective rehabilitation interventions are needed. Scanning training combined with multisensory stimulation to enhance the rehabilitation effect is suggested. In accordance, we have designed a virtual-reality based scanning training that combines visual, audio and sensori-motor stimulation called RehAtt® . Effects were shown in behavioural tests and activity of daily living. Here, we use fMRI to evaluate the change in brain activity during Posner's Cuing Task (attention task) after RehAtt® intervention, in patients with chronic neglect. Twelve patients (mean age = 72.7 years, SD = 6.1) with chronic neglect (persistent symptoms >6 months) performed the interventions 3 times/wk during 5 weeks, in total 15 hours. Training effects on brain activity were evaluated using fMRI task-evoked responses during the Posner's cuing task before and after the intervention. Patients improved their performance in the Posner fMRI task. In addition, patients increased their task-evoked brain activity after the VR interventions in an extended network including pre-frontal and temporal cortex during attentional cueing, but showed no training effec...Continue Reading

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Citations

Nov 15, 2018·Acta Neurologica Scandinavica·Anders WåhlinJan Malm
Jun 14, 2019·Neurorehabilitation and Neural Repair·Janina von der GablentzBjörn Machner
Dec 14, 2018·Frontiers in Psychology·Pietro CipressoGiuseppe Riva
Sep 19, 2020·Applied Neuropsychology. Adult·Hanne HuygelierCéline R Gillebert
Nov 17, 2020·Frontiers in Neurology·Fan Su, Wendong Xu
Aug 6, 2021·Archives of Physical Medicine and Rehabilitation·Jie HaoKa-Chun Siu

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