Increase of Glucose Uptake in Human Bone Marrow With Increasing Exercise Intensity

International Journal of Sport Nutrition and Exercise Metabolism
Ilkka H HeinonenKari K Kalliokoski

Abstract

Human bone marrow is a metabolically active tissue that responds to acute low-intensity exercise by having increased glucose uptake (GU). Here, the authors studied whether bone marrow GU increases more with increased exercise intensities. Femoral bone marrow GU was measured using positron emission tomography and [18F]-fluorodeoxyglucose in six healthy young men during cycling at intensities of 30% (low), 55% (moderate), and 75% (high) of maximal oxygen consumption on three separate days. Bone marrow GU at low was 17.2 µmol·kg-1·min-1 (range 9.0-25.4) and increased significantly (p = .003) at moderate (31.2 µmol·kg-1·min-1, 22.9-39.4) but was not significant from moderate to high (37.4 µmol·kg-1·min-1, 29.0-45.7, p = .26). Furthermore, the ratio between bone and muscle GU decreased from low to moderate exercise intensity (p < .01) but not (p = .99) from moderate to high exercise intensity. In conclusion, these results show that although the increase is not as large as observed in exercising skeletal muscle, GU in femoral bone marrow increases with increasing exercise intensity at least from low- to moderate-intensity effort, which may be important for bone and whole-body metabolic health.

References

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Jun 18, 2011·Journal of Applied Physiology·Ilkka HeinonenCraig G Crandall
Jan 3, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ilkka HeinonenKari K Kalliokoski
May 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Ilkka HeinonenKari K Kalliokoski
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Apr 19, 2016·Bone Research·Meredith L ZochRyan C Riddle
Mar 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Yung-Chih ChenDylan Thompson

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Citations

Aug 7, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Bryan HaddockFeliks Kogan
Jun 13, 2020·Current Osteoporosis Reports·R ViggersJ Starup-Linde

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