PMID: 8611659Apr 12, 1996Paper

Increase of lipid peroxidation in rat liver microsomes by dehydroepiandrosterone feeding

Biochimica Et Biophysica Acta
J SwierczynskiD Mayer

Abstract

Oral administration of the adrenal steroid dehydroepiandrosterone (DHEA), a peroxisome proliferator and hepatocarcinogen in the rat, caused an increase in NADPH-dependent lipid peroxidation in microsomes isolated from rat liver and kidney cortex, but not from brain. The increase of liver microsomal lipid peroxidation was greater in male than in female rats. the effect of DHEA on lipid peroxidation became discernible after feeding steroid-containing diet (0.6%) to male and female rats for 2 and 3 days and reached maximal levels at 1 and 2 weeks, respectively. The increase of microsomal lipid peroxidation reached a plateau stimulation at 0.05% in the diet. The addition of DHEA in the concentration range 0.1-100 microM to microsomes isolated from control rats had no effect on lipid peroxidation. Furthermore, a significant increase of the endogenous concentration of thiobarbituric acid reactive substances was found in microsomes after DHEA-administration at 0.05% in the diet. These results provide in vivo evidence that DHEA can cause lipid peroxidation in rat liver. Administration of DHEA at 0.6% in the diet for 7 consecutive days also significantly enhanced NADH- and ascorbate-dependent lipid peroxidation in liver microsomes. The ...Continue Reading

References

Jan 1, 1992·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M S RaoJ K Reddy
Jan 1, 1989·Free Radical Biology & Medicine·H Esterbauer, H Zollner

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Citations

Aug 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·J Swierczynski, D Mayer
May 22, 2003·Life Sciences·Raffaella MastrocolaGiuseppe Boccuzzi
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H P NgM L Hu
Jul 13, 1999·Free Radical Biology & Medicine·M AragnoG Boccuzzi
May 19, 1998·Journal of Endocrinological Investigation·O T Wolf, C Kirschbaum
Mar 17, 2000·Proceedings of the Society for Experimental Biology and Medicine·R J RichardsF Svec
Mar 4, 2005·Critical Reviews in Toxicology·Michelle L O'BrienHoward P Glauert
Apr 22, 2009·Experimental Cell Research·Vassilia-Ismini AlexakiElias Castanas
Mar 19, 2014·Acta Physiologica Hungarica·S EleawaHussein F Sakr
Feb 26, 2011·Steroids·Matheus Parmegiani JahnLuiz Carlos Kucharski
Sep 28, 1999·Free Radical Research·K DobashiS Nakazawa
Jan 20, 2005·American Journal of Physiology. Endocrinology and Metabolism·Tomoyuki IwasakiAtsushi Nakajima
Jul 6, 2005·Biological & Pharmaceutical Bulletin·Seher Akhtar Khan

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