Increase of neuronal nitric oxide synthase in rat skeletal muscle during ageing

Biochemical and Biophysical Research Communications
C CapanniC M Caldarera

Abstract

Nitric oxide synthases (NOS) are different widely expressed enzymes which produce the molecular messenger nitric oxide. The neuronal isoform of NOS (nNOS) is involved in several processes of the cell metabolism, most of which are, at present, not fully understood (neurotransmission, smooth muscle motility, myoblast and myocyte biology and others). In skeletal muscle nNOS is present mainly at the plasmalemma, where it is attached to the dystrophin-related proteins; in fact, in pathologies involving dystrophin, nNOS is altered as well. We report that in aged rats the nNOS amount in skeletal muscle increases both in the soluble and microsomal fractions and that an additional intracytoplasmic localisation appears.

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Citations

Mar 24, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wook SongJohn M Lawler
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