Increase of oxidized/total coenzyme Q-10 ratio in cerebrospinal fluid in patients with Parkinson's disease

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Chiaki IsobeYasuo Terayama

Abstract

The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3+/-17.9%) compared to the normal control group (68.2+/-20.4%) (p<0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development.

References

Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Jul 1, 1997·Neurology·W C Koller, E B Montgomery
Jul 17, 1998·Free Radical Biology & Medicine·M L Selley
Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·H Payami, S Zareparsi
Jun 10, 2000·Journal of Neural Transmission·F J Jiménez-JiménezJ Arenas
Dec 2, 2000·Nature Neuroscience·R BetarbetJ T Greenamyre
Aug 30, 2002·Neurotoxicology and Teratology·Michael A Collins, Edward J Neafsey
Oct 11, 2002·Archives of Neurology·Clifford W ShultsUNKNOWN Parkinson Study Group

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Citations

Feb 2, 2016·Expert Review of Neurotherapeutics·Musleh A Algarni, A Jon Stoessl
Jun 21, 2008·Life Sciences·Muralikrishnan DhanasekaranHolly Brown-Borg
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Varela-LópezJosé L Quiles
Nov 27, 2014·Frontiers in Cellular Neuroscience·Félix J Jiménez-JiménezJosé A G Agúndez
Mar 19, 2016·Acta Neurologica Scandinavica·A D AndersenJ B Gramsbergen
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Pankaj A Agarwal, A Jon Stoessl
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
Dec 17, 2008·Annals of the New York Academy of Sciences·Rajnish K Chaturvedi, M Flint Beal
Nov 2, 2007·Journal of Neurochemistry·Carine ClerenM Flint Beal

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