Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Mei-Chi HsuYao Chang

Abstract

Intratumoral cytotoxic T lymphocytes are critical for controlling tumor recurrence, and programmed death-1 (PD-1) is a recognized marker of T-cell dysfunction. We analyzed this marker and its binding ligands in nasopharyngeal tumor tissue and non-cancerous nasopharyngeal control tissue to retrospectively evaluate the correlation between its expression and the post-treatment outcome of nasopharyngeal carcinoma patients. Using double immunofluorescence staining, we found that the expression of PD-1 in CD8 T cells in tumor tissue was significantly higher than in control tissue (mean: 28.4 vs 3.9%, P<0.0001). Although the expression rate of PD-1 in intratumoral CD8 cells was not associated with the other clinicopathological parameters examined, the higher expression rate in this subset of T cells significantly correlated with a poorer prognosis of overall survival, disease-free survival, and locoregional recurrence-free survival of the cancer patients (P=0.05, 0.007, and 0.004, respectively). Multivariate analysis confirmed it as an independent risk factor for death, treatment failure, and local recurrence of nasopharyngeal carcinoma. On the other hand, the expression of PD-1 in CD4 T cells and of its ligands in epithelial and stro...Continue Reading

References

Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·M YaoM Kikuchi
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·J XuA Ahmad
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A T C ChanP J Johnson
Oct 3, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J-P SpanoJ-P Armand
Sep 25, 2004·Head & Neck·Sheng-Yow HoSen-Tien Tsai
Jun 9, 2006·The New England Journal of Medicine·Richard A Lake, Robbert G van der Most
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Houston ThompsonEugene D Kwon
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takeo NomiYoshiyuki Nakajima
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Oct 7, 2008·Oncogene·T J Stewart, S I Abrams
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiang GaoJia Fan
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joaquim CarrerasElias Campo
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianxiong WangYang Yang
Jun 13, 2009·Blood·Jon C Aster
Sep 16, 2009·Immunology Letters·Raymond M WongAdrian I Bot
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rezaul KarimSjoerd H van der Burg

❮ Previous
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Citations

Sep 29, 2011·The Cancer Journal·Michael PostowJedd D Wolchok
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael R GreenMargaret A Shipp
May 14, 2014·Oral Oncology·Dan P Zandberg, Scott E Strome
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J ChenX D Zhang
Feb 6, 2013·Cytokine & Growth Factor Reviews·Simone MocellinPierluigi Pilati
Jan 5, 2016·Cancer Immunology, Immunotherapy : CII·Shamaila Munir AhmadMads Hald Andersen
Apr 30, 2015·Journal of Cancer Research and Clinical Oncology·Sharon D StokerJan Paul de Boer
Jul 18, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaemoon KohDoo Hyun Chung
Jun 11, 2015·Journal of Oncology·Hina KhanIuliana Shapira
Sep 14, 2013·Critical Reviews in Oncology/hematology·Barbara MerelliMario Mandalà
Jan 9, 2014·Hematology/oncology and Stem Cell Therapy·Sehar Afreen, Said Dermime
May 7, 2016·Journal of Cutaneous Pathology·Nathaniel A Slater, Paul B Googe
Sep 14, 2016·Oral Oncology·Chloé RancouleNicolas Magné
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeAnthony T C Chan
Apr 28, 2017·Expert Opinion on Investigational Drugs·Brigette B Y MaAnthony T C Chan
Nov 25, 2017·Head & Neck·Cory D FulcherUNKNOWN Education Committee of the American Head and Neck Society (AHNS)
Jan 23, 2018·Head & Neck·Cristina RiobelloMario A Hermsen
Feb 9, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna Maria WirsingElin Hadler-Olsen
Jan 18, 2020·International Journal of Cancer. Journal International Du Cancer·Liam MastersonMatt Lechner
Mar 20, 2020·American Society of Clinical Oncology Educational Book·Brigette B Y MaJun Ma
Mar 20, 2020·PloS One·Soehartati A GondhowiardjoTiara Bunga Mayang Permata
Jun 24, 2017·Immunogenetics·Arash SalmaninejadSayed Mostafa Hosseini
Jun 13, 2019·Oncology Letters·Hyung-Wook Chun, Ran Hong

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