Increase of resistance to stretch during the latent period in single muscle fibres of the frog

Acta Physiologica Scandinavica
P Haugen

Abstract

The time from stimulation to the first change of the extensibility in an isolated skeletal muscle fibre was measured by subjecting the fibre to a rapid, small stretch at various times during the latent period. The experiments were performed at constant temperatures in the range 1-16 degrees C. Irrespective of the temperature, the first increase of the resistance to stretch occurred after the onset of the latency relaxation. At a temperature or 10 degrees C and a sarcomere length of 3 microgram the resistance started to increase 5.5 ms after stimulation, i.e. 1.5-2 ms after the onset of the drop in tension, and then increased nearly linearly with time. Corresponding to the end of the latent period, i.e. when the tension recrosses the resting level, the amplitude of the response was about 1.5 times its resting value. There was an interval between the onset of increase f the resistance to stretch and the time when the rate of drop in tension had passed its maximum value. The results are compatible with the hypothesis that the latency relaxation arises from a minute lengthening of the thin filaments as proposed by Haugen & Sten-Knudsen, and that attachment and generation of force take place at separate steps of the cross-bridge cycle.

References

May 1, 1978·The Journal of Physiology·I Matsubara, N Yagi
Sep 1, 1976·The Journal of General Physiology·P Haugen, O Sten-Knudsen
Mar 15, 1974·Biochemical and Biophysical Research Communications·M Herbst, P Piontek
Jun 1, 1981·Acta Physiologica Scandinavica·P Haugen, O Sten-Knudsen
Apr 1, 1980·Acta Physiologica Scandinavica·A Kirkebø, I Tyssebotn
Jul 15, 1953·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
Oct 13, 1950·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
Jul 24, 1950·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
Jun 23, 1949·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
May 30, 1947·Annals of the New York Academy of Sciences·A SANDOW

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Citations

Jun 1, 1987·Pflügers Archiv : European journal of physiology·G CecchiG Piazzesi
Apr 1, 1987·Journal of Muscle Research and Cell Motility·P Haugen, O Sten-Knudsen

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