Increase of toll-like receptor 4 but decrease of interleukin-8 mRNA expression among ischemic stroke patients under aspirin treatment

Clinical Biochemistry
Dean WuChaur-Jong Hu

Abstract

Toll-like receptors (TLRs) are molecules conserved in evolution for detecting pathogen invasions and tissue damage and are involved in atherogenesis. This study explores the mRNA expression of TLRs and their probable role in further disease occurrence among ischemic stroke patients. A total of 89 ischemic stroke patients and 166 controls were recruited for this study. Total RNA was extracted and mRNA was reverse-transcribed to cDNA and was analyzed for TLRs and interleukin 8 (IL8). The TLR4 mRNA expression level is significantly higher in the stroke group. Conversely, IL-8 mRNA levels decreased significantly in the patient group. Our results suggest that TLR4 overexpression in mRNA levels is observed in stroke patients, which might account for the probable inflammatory injury before or after stroke. A reduction of IL-8 expression could result from the downregulatory effects of aspirin.

References

Feb 27, 1999·Current Opinion in Immunology·E B Kopp, R Medzhitov
Apr 10, 1999·The Journal of Biological Chemistry·J C ChowF Gusovsky
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Nov 24, 1999·Atherosclerosis·T J Reape, P H Groot
Jan 21, 2001·The Journal of Biological Chemistry·Y OkamuraJ F Strauss
Jan 10, 2002·The Journal of Experimental Medicine·Christian TermeerJan Christoph Simon
Mar 15, 2002·The Lancet Infectious Diseases·Maija Leinonen, Pekka Saikku
Jul 19, 2002·The New England Journal of Medicine·Stefan KiechlDavid A Schwartz
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Murat V KalayogluGerald I Byrne
May 14, 2003·Circulation·S Matthijs BoekholdtUNKNOWN REgression GRowth Evaluation Statin Study Group
Sep 6, 2003·Atherosclerosis·Ian A YangUNKNOWN Southampton Atherosclerosis Study (SAS) Group
May 19, 2004·European Journal of Clinical Investigation·G PasterkampD P V De Kleijn
Jul 20, 2004·Journal of Neurology·Peter ReismannAngelika Bierhaus
Sep 24, 2008·Neuroscience·B J MarshM P Stenzel-Poore
Jan 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David BreaJosé Castillo

❮ Previous
Next ❯

Citations

Apr 12, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Margarida Freitas-SilvaJosé Pedro Nunes
Apr 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Walaa A KeshkAzza A Ghali
Oct 28, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lian GuQianli Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
David BreaJosé Castillo
European Journal of Clinical Investigation
Gerard PasterkampDominique P V de Kleijn
The New England Journal of Medicine
R Ross
© 2021 Meta ULC. All rights reserved