Increased α-Linolenic Acid Intake during Pregnancy is Associated with Higher Offspring Birth Weight

Current Developments in Nutrition
Melinda PhangMichael R Skilton

Abstract

The amount and type of fat in the maternal diet during pregnancy are important contributors to fetal growth. The importance of plant-based omega-3 fatty acid (α-linolenic acid, ALA) intake in fetal growth has not been previously examined. We sought to determine the association of maternal ALA intake during pregnancy with birth weight and body composition of the offspring. Mothers and their newborn infants (n = 224) were recruited from the Royal Prince Alfred Hospital, Australia. Maternal diet during pregnancy was assessed using a validated food frequency questionnaire. Plasma fatty acid composition was analyzed in a subset of mothers (n = 41). Newborn body composition was assessed using air-displacement plethysmography. All analyses were adjusted for gestational age, sex, physical activity, and total energy intake. Dietary fatty acid intakes were positively associated with plasma phospholipid fatty acids for total omega-3 fatty acids (β = 0.452, P = 0.003), ALA (β = 0.339, P = 0.03), linoleic acid (β = 0.353, P = 0.03), eicosapentaenoic acid (β = 0.407, P = 0.009), and docosahexaenoic acid (β = 0.388, P = 0.01). Higher maternal intake of ALA (% total fat) was associated with higher offspring birth weight [189.7-g increase per 1...Continue Reading

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Citations

Jan 17, 2020·The American Journal of Clinical Nutrition·Melinda PhangMichael R Skilton
May 1, 2021·Nutrients·Kirsty M MckenzieMichael R Skilton
Jun 2, 2021·Journal of Tropical Pediatrics·Rafaela Cristina Vieira E SouzaLuana Caroline Dos Santos
Oct 1, 2021·The American Journal of Clinical Nutrition·Nicholas A KoemelMichael R Skilton

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BETA
blood collection
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